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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]
| Target ID |
GM-T77410
|
| Target Name |
BMP-4/BMP4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
652
|
| Gene ID |
100034048 (Equus caballus), 101100311 (Felis catus), 12159 (Mus musculus), 25296 (Rattus norvegicus)
407216 (Bos taurus), 490695 (Canis lupus familiaris), 652 (Homo sapiens), 694618 (Macaca mulatta)
|
| Target Alternative Names |
BMP4,Bmp4,Bmp-4,Bmp2b,Bmp2b1,Bmp2b-1,BOMPR4A,ZYME,BMP2B,OFC11,BMP2B1,MCOPS6
|
| Uniprot Accession |
P21275,Q06826,Q2KJH1,P12644
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thyroid hormone signaling pathway, Pathways in cancer, Basal cell carcinoma, Fluid shear stress and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000017676, ENSMUSG00000021835, ENSBTAG00000003835, ENSCAFG00845004370, ENSG00000125378, ENSMMUG00000000429
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of BMP-4/BMP4 cDNA Clones/ORF Plasmid
BMP-4/BMP4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo652 | Pre-made Human BMP4/ZYME/BMP2B siRNA oligo Duplex | 652 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25296 | Pre-made Rat Bmp4/BOMPR4A siRNA oligo Duplex | 25296 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12159 | Pre-made Mouse Bmp4/Bmp-4/Bmp2b siRNA oligo Duplex | 12159 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo694618 | Pre-made Cynomolgus/Rhesus macaque BMP4 siRNA oligo Duplex | 694618 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100311 | Pre-made Cat/Feline BMP4 siRNA oligo Duplex | 101100311 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo490695 | Pre-made Dog/Canine BMP4 siRNA oligo Duplex | 490695 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407216 | Pre-made Bovines/Cattle BMP4 siRNA oligo Duplex | 407216 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034048 | Pre-made Equine/Horse BMP4 siRNA oligo Duplex | 100034048 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BMP-4/BMP4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T77410-Ab | Human | Anti-Human BMP-4/BMP4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T77410-Ab | Rat | Anti-Rat BMP-4/BMP4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T77410-Ab | Mouse | Anti-Mouse BMP-4/BMP4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T77410-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BMP-4/BMP4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T77410-Ab | Cat/Feline | Anti-Cat/Feline BMP-4/BMP4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T77410-Ab | Dog/Canine | Anti-Dog/Canine BMP-4/BMP4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T77410-Ab | Bovines/Cattle | Anti-Bovines/Cattle BMP-4/BMP4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T77410-Ab | Equine/Horse | Anti-Equine/Horse BMP-4/BMP4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
BMP-4/BMP4 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T77410-Ag | Human | Human BMP-4/BMP4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T77410-Ag | Rat | Rat BMP-4/BMP4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T77410-Ag | Mouse | Mouse BMP-4/BMP4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T77410-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BMP-4/BMP4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T77410-Ag | Cat/Feline | Cat/Feline BMP-4/BMP4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T77410-Ag | Dog/Canine | Dog/Canine BMP-4/BMP4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T77410-Ag | Bovines/Cattle | Bovines/Cattle BMP-4/BMP4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T77410-Ag | Equine/Horse | Equine/Horse BMP-4/BMP4 recombinant protein | Mammalian cell | Detail |
