Recombinant multi-species NOD2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NOD2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
The Alternative Names of target: ACUG,BLAU,BLAUS,CARD15,CD,CLR16.3,Card15,Caspase recruitment domain-containing protein 15,F830032C23Rik,IBD1,Inflammatory bowel disease protein 1,NLRC2,NOD2,NOD2B,Nlrc2,Nod2,Nucleotide-binding oligomerization domain-containing protein 2,PSORAS1,YAOS

Target products collectionGo to NOD2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T75643-Ag-1/ GM-Tg-hg-T75643-Ag-2 Human NOD2 protein Human
GM-Tg-rg-T75643-Ag-1/ GM-Tg-rg-T75643-Ag-2 Rat NOD2 protein Rat
GM-Tg-mg-T75643-Ag-1/ GM-Tg-mg-T75643-Ag-2 Mouse NOD2 protein Mouse
GM-Tg-cynog-T75643-Ag-1/ GM-Tg-cynog-T75643-Ag-2 Cynomolgus/Rhesus macaque NOD2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T75643-Ag-1/ GM-Tg-felg-T75643-Ag-2 Feline NOD2 protein Feline
GM-Tg-cang-T75643-Ag-1/ GM-Tg-cang-T75643-Ag-2 Canine NOD2 protein Canine
GM-Tg-bovg-T75643-Ag-1/ GM-Tg-bovg-T75643-Ag-2 Bovine NOD2 protein Bovine
GM-Tg-equg-T75643-Ag-1/ GM-Tg-equg-T75643-Ag-2 Equine NOD2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T75643-Ag-1/ GM-Tg-hg-T75643-Ag-2; GM-Tg-rg-T75643-Ag-1/ GM-Tg-rg-T75643-Ag-2;
GM-Tg-mg-T75643-Ag-1/ GM-Tg-mg-T75643-Ag-2; GM-Tg-cynog-T75643-Ag-1/ GM-Tg-cynog-T75643-Ag-2;
GM-Tg-felg-T75643-Ag-1/ GM-Tg-felg-T75643-Ag-2; GM-Tg-cang-T75643-Ag-1/ GM-Tg-cang-T75643-Ag-2;
GM-Tg-bovg-T75643-Ag-1/ GM-Tg-bovg-T75643-Ag-2; GM-Tg-equg-T75643-Ag-1/ GM-Tg-equg-T75643-Ag-2
Products Name NOD2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name NOD2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NOD2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.