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Target
sublocation: Introcelluar Protein.
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
| Target ID |
GM-T75643
|
| Target Name |
NOD2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
64127
|
| Gene ID |
100059123 (Equus caballus), 101096863 (Felis catus), 257632 (Mus musculus), 291912 (Rattus norvegicus)
444867 (Bos taurus), 487286 (Canis lupus familiaris), 64127 (Homo sapiens), 695542 (Macaca mulatta)
|
| Target Alternative Names |
ACUG,BLAU,BLAUS,CARD15,CD,CLR16.3,Card15,Caspase recruitment domain-containing protein 15,F830032C23Rik,IBD1,Inflammatory bowel disease protein 1,NLRC2,NOD2,NOD2B,Nlrc2,Nod2,Nucleotide-binding oligomerization domain-containing protein 2,PSORAS1,YAOS
|
| Uniprot Accession |
Q8K3Z0,Q6E804,Q9HC29
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
NOD-like receptor signaling pathway, TNF signaling pathway, Tuberculosis, Inflammatory bowel disease
|
| Gene Ensembl |
ENSECAG00000017005, ENSMUSG00000055994, ENSBTAG00000020936, ENSCAFG00845003875, ENSG00000167207, ENSMMUG00000012207
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of NOD2 cDNA Clones/ORF Plasmid
NOD2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo64127 | Pre-made Human NOD2/CD/ACUG siRNA oligo Duplex | 64127 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo291912 | Pre-made Rat Nod2/Card15 siRNA oligo Duplex | 291912 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo257632 | Pre-made Mouse Nod2/CD/ACUG siRNA oligo Duplex | 257632 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695542 | Pre-made Cynomolgus/Rhesus macaque NOD2 siRNA oligo Duplex | 695542 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096863 | Pre-made Cat/Feline NOD2 siRNA oligo Duplex | 101096863 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487286 | Pre-made Dog/Canine NOD2 siRNA oligo Duplex | 487286 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo444867 | Pre-made Bovines/Cattle NOD2/CARD15 siRNA oligo Duplex | 444867 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100059123 | Pre-made Equine/Horse NOD2 siRNA oligo Duplex | 100059123 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NOD2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T75643-Ab | Human | Anti-Human NOD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T75643-Ab | Rat | Anti-Rat NOD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T75643-Ab | Mouse | Anti-Mouse NOD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T75643-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NOD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T75643-Ab | Cat/Feline | Anti-Cat/Feline NOD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T75643-Ab | Dog/Canine | Anti-Dog/Canine NOD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T75643-Ab | Bovines/Cattle | Anti-Bovines/Cattle NOD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T75643-Ab | Equine/Horse | Anti-Equine/Horse NOD2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
NOD2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T75643-Ag | Human | Human NOD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T75643-Ag | Rat | Rat NOD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T75643-Ag | Mouse | Mouse NOD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T75643-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NOD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T75643-Ag | Cat/Feline | Cat/Feline NOD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T75643-Ag | Dog/Canine | Dog/Canine NOD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T75643-Ag | Bovines/Cattle | Bovines/Cattle NOD2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T75643-Ag | Equine/Horse | Equine/Horse NOD2 recombinant protein | Mammalian cell | Detail |
