Recombinant multi-species MTOR/mTOR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MTOR/mTOR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]
The Alternative Names of target: 2610315D21Rik,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,FRAP,FRAP1,FRAP2,Frap1,MTOR,Mammalian target of rapamycin (mTOR),Mechanistic target of rapamycin,Mtor,RAFT1,RAPT1,Rapamycin and FKBP12 target 1,Rapamycin target protein 1,SKS,Serine/threonine-protein kinase mTOR,Tyrosine-protein kinase mTOR,flat,mTOR

Target products collectionGo to MTOR/mTOR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T75243-Ag-1/ GM-Tg-hg-T75243-Ag-2 Human MTOR/mTOR protein Human
GM-Tg-rg-T75243-Ag-1/ GM-Tg-rg-T75243-Ag-2 Rat MTOR/mTOR protein Rat
GM-Tg-mg-T75243-Ag-1/ GM-Tg-mg-T75243-Ag-2 Mouse MTOR/mTOR protein Mouse
GM-Tg-cynog-T75243-Ag-1/ GM-Tg-cynog-T75243-Ag-2 Cynomolgus/Rhesus macaque MTOR/mTOR protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T75243-Ag-1/ GM-Tg-felg-T75243-Ag-2 Feline MTOR/mTOR protein Feline
GM-Tg-cang-T75243-Ag-1/ GM-Tg-cang-T75243-Ag-2 Canine MTOR/mTOR protein Canine
GM-Tg-bovg-T75243-Ag-1/ GM-Tg-bovg-T75243-Ag-2 Bovine MTOR/mTOR protein Bovine
GM-Tg-equg-T75243-Ag-1/ GM-Tg-equg-T75243-Ag-2 Equine MTOR/mTOR protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T75243-Ag-1/ GM-Tg-hg-T75243-Ag-2; GM-Tg-rg-T75243-Ag-1/ GM-Tg-rg-T75243-Ag-2;
GM-Tg-mg-T75243-Ag-1/ GM-Tg-mg-T75243-Ag-2; GM-Tg-cynog-T75243-Ag-1/ GM-Tg-cynog-T75243-Ag-2;
GM-Tg-felg-T75243-Ag-1/ GM-Tg-felg-T75243-Ag-2; GM-Tg-cang-T75243-Ag-1/ GM-Tg-cang-T75243-Ag-2;
GM-Tg-bovg-T75243-Ag-1/ GM-Tg-bovg-T75243-Ag-2; GM-Tg-equg-T75243-Ag-1/ GM-Tg-equg-T75243-Ag-2
Products Name MTOR/mTOR protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MTOR/mTOR
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MTOR/mTOR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.