Explore MTOR/mTOR gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]
| Target ID |
GM-T75243
|
| Target Name |
MTOR/mTOR
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2475
|
| Gene ID |
100051341 (Equus caballus), 100139219 (Bos taurus), 101098152 (Felis catus), 106992736 (Macaca mulatta) 2475 (Homo sapiens), 56717 (Mus musculus), 56718 (Rattus norvegicus)
|
| Target Alternative Names |
2610315D21Rik,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,FRAP,FRAP1,FRAP2,Frap1,MTOR,Mammalian target of rapamycin (mTOR),Mechanistic target of rapamycin,Mtor,RAFT1,RAPT1,Rapamycin and FKBP12 target 1,Rapamycin target protein 1,SKS,Serine/threonine-protein kinase mTOR,Tyrosine-protein kinase mTOR,flat,mTOR
|
| Uniprot Accession |
P42345,Q9JLN9,P42346
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Non-Small Cell Lung Cancer
|
| Disease from KEGG |
EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, JAK-STAT signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer
|
| Gene Ensembl |
ENSECAG00000015638, ENSBTAG00000015325, ENSMMUG00000019325, ENSG00000198793, ENSMUSG00000028991
|
| Target Classification |
Kinase
|
Pre-made viral vector of MTOR/mTOR cDNA Clones/ORF Plasmid
MTOR/mTOR siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2475 | Pre-made Human MTOR/SKS/FRAP siRNA oligo Duplex | 2475 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo56718 | Pre-made Rat Mtor/Frap1/RAFT1 siRNA oligo Duplex | 56718 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo56717 | Pre-made Mouse Mtor/FRAP/flat siRNA oligo Duplex | 56717 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo106992736 | Pre-made Cynomolgus/Rhesus macaque MTOR siRNA oligo Duplex | 106992736 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101098152 | Pre-made Cat/Feline MTOR siRNA oligo Duplex | 101098152 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100139219 | Pre-made Bovines/Cattle MTOR siRNA oligo Duplex | 100139219 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051341 | Pre-made Equine/Horse MTOR siRNA oligo Duplex | 100051341 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MTOR/mTOR antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T75243-Ab | Human | Anti-Human MTOR/mTOR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T75243-Ab | Rat | Anti-Rat MTOR/mTOR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T75243-Ab | Mouse | Anti-Mouse MTOR/mTOR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T75243-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MTOR/mTOR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T75243-Ab | Cat/Feline | Anti-Cat/Feline MTOR/mTOR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T75243-Ab | Bovines/Cattle | Anti-Bovines/Cattle MTOR/mTOR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T75243-Ab | Equine/Horse | Anti-Equine/Horse MTOR/mTOR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
MTOR/mTOR recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T75243-Ag | Human | Human MTOR/mTOR recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T75243-Ag | Rat | Rat MTOR/mTOR recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T75243-Ag | Mouse | Mouse MTOR/mTOR recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T75243-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MTOR/mTOR recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T75243-Ag | Cat/Feline | Cat/Feline MTOR/mTOR recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T75243-Ag | Bovines/Cattle | Bovines/Cattle MTOR/mTOR recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T75243-Ag | Equine/Horse | Equine/Horse MTOR/mTOR recombinant protein | Mammalian cell | Detail |