MTOR/mTOR Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore MTOR/mTOR gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]

Target ID GM-T75243
Target Name MTOR/mTOR
Gene Group ldentifer
(Target Gene ID in Homo species)
2475
Gene ID 100051341 (Equus caballus), 100139219 (Bos taurus), 101098152 (Felis catus), 106992736 (Macaca mulatta)
2475 (Homo sapiens), 56717 (Mus musculus), 56718 (Rattus norvegicus)
Target Alternative Names 2610315D21Rik,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,FRAP,FRAP1,FRAP2,Frap1,MTOR,Mammalian target of rapamycin (mTOR),Mechanistic target of rapamycin,Mtor,RAFT1,RAPT1,Rapamycin and FKBP12 target 1,Rapamycin target protein 1,SKS,Serine/threonine-protein kinase mTOR,Tyrosine-protein kinase mTOR,flat,mTOR
Uniprot Accession P42345,Q9JLN9,P42346
Protein Sub-location Introcelluar Protein
Category Therapeutics Target
Disease cancer, Non-Small Cell Lung Cancer
Disease from KEGG EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, JAK-STAT signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Ensembl ENSECAG00000015638, ENSBTAG00000015325, ENSMMUG00000019325, ENSG00000198793, ENSMUSG00000028991
Target Classification Kinase


Pre-made viral vector of MTOR/mTOR cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLP005595Human MTOR/FRAP/FRAP1 Lentivirus plasmidNM_004958.32475HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLP005595Human MTOR/FRAP/FRAP1 Lentivirus particleNM_004958.32475HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail


MTOR/mTOR siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo2475Pre-made Human MTOR/SKS/FRAP siRNA oligo Duplex2475HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo56718Pre-made Rat Mtor/Frap1/RAFT1 siRNA oligo Duplex56718RatIn-vitro grade; in-vivo gradeDetail
pGMoligo56717Pre-made Mouse Mtor/FRAP/flat siRNA oligo Duplex56717MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo106992736Pre-made Cynomolgus/Rhesus macaque MTOR siRNA oligo Duplex106992736Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo101098152Pre-made Cat/Feline MTOR siRNA oligo Duplex101098152Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo100139219Pre-made Bovines/Cattle MTOR siRNA oligo Duplex100139219Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100051341Pre-made Equine/Horse MTOR siRNA oligo Duplex100051341Equine/HorseIn-vitro grade; in-vivo gradeDetail


MTOR/mTOR antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T75243-AbHumanAnti-Human MTOR/mTOR monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-rg-T75243-AbRatAnti-Rat MTOR/mTOR monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-mg-T75243-AbMouseAnti-Mouse MTOR/mTOR monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cynog-T75243-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque MTOR/mTOR monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-felg-T75243-AbCat/FelineAnti-Cat/Feline MTOR/mTOR monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-bovg-T75243-AbBovines/CattleAnti-Bovines/Cattle MTOR/mTOR monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-equg-T75243-AbEquine/HorseAnti-Equine/Horse MTOR/mTOR monoclonal antibodymabTherapeutics Target antibodyDetail


MTOR/mTOR recombinant protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T75243-AgHumanHuman MTOR/mTOR recombinant proteinMammalian cellDetail
GM-Tg-rg-T75243-AgRatRat MTOR/mTOR recombinant proteinMammalian cellDetail
GM-Tg-mg-T75243-AgMouseMouse MTOR/mTOR recombinant proteinMammalian cellDetail
GM-Tg-cynog-T75243-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque MTOR/mTOR recombinant proteinMammalian cellDetail
GM-Tg-felg-T75243-AgCat/FelineCat/Feline MTOR/mTOR recombinant proteinMammalian cellDetail
GM-Tg-bovg-T75243-AgBovines/CattleBovines/Cattle MTOR/mTOR recombinant proteinMammalian cellDetail
GM-Tg-equg-T75243-AgEquine/HorseEquine/Horse MTOR/mTOR recombinant proteinMammalian cellDetail