Recombinant multi-species WISP1/CCN4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine WISP1/CCN4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
The Alternative Names of target: WISP1, CCN4,CCN family member 4,WNT1-inducible-signaling pathway protein 1 (WISP-1), Wnt-1-induced secreted protein,WISP1,WISP1c,WISP1i,WISP1tc,WISP1-OT1,WISP1-UT1

Target products collectionGo to WISP1/CCN4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T71859-Ab-1/ GM-Tg-hg-T71859-Ab-2 Human WISP1/CCN4 protein Human
GM-Tg-rg-T71859-Ab-1/ GM-Tg-rg-T71859-Ab-2 Rat WISP1/CCN4 protein Rat
GM-Tg-mg-T71859-Ab-1/ GM-Tg-mg-T71859-Ab-2 Mouse WISP1/CCN4 protein Mouse
GM-Tg-cynog-T71859-Ab-1/ GM-Tg-cynog-T71859-Ab-2 Cynomolgus/Rhesus macaque WISP1/CCN4 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T71859-Ab-1/ GM-Tg-felg-T71859-Ab-2 Feline WISP1/CCN4 protein Feline
GM-Tg-cang-T71859-Ab-1/ GM-Tg-cang-T71859-Ab-2 Canine WISP1/CCN4 protein Canine
GM-Tg-bovg-T71859-Ab-1/ GM-Tg-bovg-T71859-Ab-2 Bovine WISP1/CCN4 protein Bovine
GM-Tg-equg-T71859-Ab-1/ GM-Tg-equg-T71859-Ab-2 Equine WISP1/CCN4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T71859-Ab-1/ GM-Tg-hg-T71859-Ab-2; GM-Tg-rg-T71859-Ab-1/ GM-Tg-rg-T71859-Ab-2;
GM-Tg-mg-T71859-Ab-1/ GM-Tg-mg-T71859-Ab-2; GM-Tg-cynog-T71859-Ab-1/ GM-Tg-cynog-T71859-Ab-2;
GM-Tg-felg-T71859-Ab-1/ GM-Tg-felg-T71859-Ab-2; GM-Tg-cang-T71859-Ab-1/ GM-Tg-cang-T71859-Ab-2;
GM-Tg-bovg-T71859-Ab-1/ GM-Tg-bovg-T71859-Ab-2; GM-Tg-equg-T71859-Ab-1/ GM-Tg-equg-T71859-Ab-2
Products Name WISP1/CCN4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name WISP1/CCN4
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine WISP1/CCN4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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