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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
Target ID |
GM-T71859
|
Target Name |
WISP1/CCN4
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
8840
|
Gene ID |
100068971 (Equus caballus), 101093993 (Felis catus), 22402 (Mus musculus), 482048 (Canis lupus familiaris) 539163 (Bos taurus), 65154 (Rattus norvegicus), 697624 (Macaca mulatta), 8840 (Homo sapiens)
|
Target Alternative Names |
CCN4,Ccn4,WISP1,Elm1,Wisp1,WISP1c,WISP1i,WISP1tc,WISP1-OT1,WISP1-UT1
|
Uniprot Accession |
O54775,Q99PP0,O95388
|
Uniprot Entry Name |
|
Protein Sub-location |
Secreted Protein/Potential Cytokines
|
Category |
Therapeutics Target, Cytokine Target
|
Disease |
cancer, Breast Cancer
|
Disease from KEGG |
Wnt signaling pathway
|
Gene Ensembl |
ENSECAG00000025050, ENSMUSG00000005124, ENSCAFG00845009509, ENSBTAG00000000707, ENSMMUG00000010199, ENSG00000104415
|
Target Classification |
|
Pre-made viral vector of WISP1/CCN4 cDNA Clones/ORF Plasmid
WISP1/CCN4 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo8840 | Pre-made Human CCN4/WISP1/WISP1c siRNA oligo Duplex | 8840 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo65154 | Pre-made Rat Ccn4/Wisp1 siRNA oligo Duplex | 65154 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo22402 | Pre-made Mouse Ccn4/Elm1/Wisp1 siRNA oligo Duplex | 22402 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo697624 | Pre-made Cynomolgus/Rhesus macaque CCN4/WISP1 siRNA oligo Duplex | 697624 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101093993 | Pre-made Cat/Feline CCN4/WISP1 siRNA oligo Duplex | 101093993 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo482048 | Pre-made Dog/Canine CCN4/WISP1 siRNA oligo Duplex | 482048 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo539163 | Pre-made Bovines/Cattle CCN4/WISP1 siRNA oligo Duplex | 539163 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100068971 | Pre-made Equine/Horse CCN4/WISP1 siRNA oligo Duplex | 100068971 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
WISP1/CCN4 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T71859-Ab | Human | Anti-Human WISP1/CCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-rg-T71859-Ab | Rat | Anti-Rat WISP1/CCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-mg-T71859-Ab | Mouse | Anti-Mouse WISP1/CCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cynog-T71859-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque WISP1/CCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-felg-T71859-Ab | Cat/Feline | Anti-Cat/Feline WISP1/CCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cang-T71859-Ab | Dog/Canine | Anti-Dog/Canine WISP1/CCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-bovg-T71859-Ab | Bovines/Cattle | Anti-Bovines/Cattle WISP1/CCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-equg-T71859-Ab | Equine/Horse | Anti-Equine/Horse WISP1/CCN4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
WISP1/CCN4 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T71859-Ag | Human | Human WISP1/CCN4 recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T71859-Ag | Rat | Rat WISP1/CCN4 recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T71859-Ag | Mouse | Mouse WISP1/CCN4 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T71859-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque WISP1/CCN4 recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T71859-Ag | Cat/Feline | Cat/Feline WISP1/CCN4 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T71859-Ag | Dog/Canine | Dog/Canine WISP1/CCN4 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T71859-Ag | Bovines/Cattle | Bovines/Cattle WISP1/CCN4 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T71859-Ag | Equine/Horse | Equine/Horse WISP1/CCN4 recombinant protein | Mammalian cell | Detail |