WISP1/CCN4 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore WISP1/CCN4 gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]

Target ID GM-T71859
Target Name WISP1/CCN4
Gene Group ldentifer
(Target Gene ID in Homo species)
8840
Gene ID 100068971 (Equus caballus), 101093993 (Felis catus), 22402 (Mus musculus), 482048 (Canis lupus familiaris)
539163 (Bos taurus), 65154 (Rattus norvegicus), 697624 (Macaca mulatta), 8840 (Homo sapiens)
Target Alternative Names CCN4,Ccn4,WISP1,Elm1,Wisp1,WISP1c,WISP1i,WISP1tc,WISP1-OT1,WISP1-UT1
Uniprot Accession O54775,Q99PP0,O95388
Uniprot Entry Name
Protein Sub-location Secreted Protein/Potential Cytokines
Category Therapeutics Target, Cytokine Target
Disease cancer, Breast Cancer
Disease from KEGG Wnt signaling pathway
Gene Ensembl ENSECAG00000025050, ENSMUSG00000005124, ENSCAFG00845009509, ENSBTAG00000000707, ENSMMUG00000010199, ENSG00000104415
Target Classification


Pre-made viral vector of WISP1/CCN4 cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLP003599Human WISP1/CCN4/WISP1-OT1 Lentivirus plasmidNM_0038828840HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLP003599Human WISP1/CCN4/WISP1-OT1 Lentivirus particleNM_0038828840HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail


WISP1/CCN4 siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo8840Pre-made Human CCN4/WISP1/WISP1c siRNA oligo Duplex8840HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo65154Pre-made Rat Ccn4/Wisp1 siRNA oligo Duplex65154RatIn-vitro grade; in-vivo gradeDetail
pGMoligo22402Pre-made Mouse Ccn4/Elm1/Wisp1 siRNA oligo Duplex22402MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo697624Pre-made Cynomolgus/Rhesus macaque CCN4/WISP1 siRNA oligo Duplex697624Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo101093993Pre-made Cat/Feline CCN4/WISP1 siRNA oligo Duplex101093993Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo482048Pre-made Dog/Canine CCN4/WISP1 siRNA oligo Duplex482048Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo539163Pre-made Bovines/Cattle CCN4/WISP1 siRNA oligo Duplex539163Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100068971Pre-made Equine/Horse CCN4/WISP1 siRNA oligo Duplex100068971Equine/HorseIn-vitro grade; in-vivo gradeDetail


WISP1/CCN4 antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T71859-AbHumanAnti-Human WISP1/CCN4 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-rg-T71859-AbRatAnti-Rat WISP1/CCN4 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-mg-T71859-AbMouseAnti-Mouse WISP1/CCN4 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-cynog-T71859-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque WISP1/CCN4 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-felg-T71859-AbCat/FelineAnti-Cat/Feline WISP1/CCN4 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-cang-T71859-AbDog/CanineAnti-Dog/Canine WISP1/CCN4 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-bovg-T71859-AbBovines/CattleAnti-Bovines/Cattle WISP1/CCN4 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail
GM-Tg-equg-T71859-AbEquine/HorseAnti-Equine/Horse WISP1/CCN4 monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibodyDetail


WISP1/CCN4 recombinant protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T71859-AgHumanHuman WISP1/CCN4 recombinant proteinMammalian cellDetail
GM-Tg-rg-T71859-AgRatRat WISP1/CCN4 recombinant proteinMammalian cellDetail
GM-Tg-mg-T71859-AgMouseMouse WISP1/CCN4 recombinant proteinMammalian cellDetail
GM-Tg-cynog-T71859-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque WISP1/CCN4 recombinant proteinMammalian cellDetail
GM-Tg-felg-T71859-AgCat/FelineCat/Feline WISP1/CCN4 recombinant proteinMammalian cellDetail
GM-Tg-cang-T71859-AgDog/CanineDog/Canine WISP1/CCN4 recombinant proteinMammalian cellDetail
GM-Tg-bovg-T71859-AgBovines/CattleBovines/Cattle WISP1/CCN4 recombinant proteinMammalian cellDetail
GM-Tg-equg-T71859-AgEquine/HorseEquine/Horse WISP1/CCN4 recombinant proteinMammalian cellDetail