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Recombinant multi-species Complement factor H/CFH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Complement factor H/CFH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
The Alternative Names of target: AHUS1,AMBP1,ARMD4,ARMS1,CFH,CFH-L,CFHL3,Cfh,Complement factor H,FH,FHL1,H factor 1,HF,HF1,HF2,HUS,Mud-1,NOM,Sas-1,Sas1
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MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T71086-Ag-1/ GM-Tg-hg-T71086-Ag-2 | Human Complement factor H/CFH protein | Human |
| GM-Tg-rg-T71086-Ag-1/ GM-Tg-rg-T71086-Ag-2 | Rat Complement factor H/CFH protein | Rat |
| GM-Tg-mg-T71086-Ag-1/ GM-Tg-mg-T71086-Ag-2 | Mouse Complement factor H/CFH protein | Mouse |
| GM-Tg-cynog-T71086-Ag-1/ GM-Tg-cynog-T71086-Ag-2 | Cynomolgus/Rhesus macaque Complement factor H/CFH protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T71086-Ag-1/ GM-Tg-felg-T71086-Ag-2 | Feline Complement factor H/CFH protein | Feline |
| GM-Tg-cang-T71086-Ag-1/ GM-Tg-cang-T71086-Ag-2 | Canine Complement factor H/CFH protein | Canine |
| GM-Tg-bovg-T71086-Ag-1/ GM-Tg-bovg-T71086-Ag-2 | Bovine Complement factor H/CFH protein | Bovine |
| GM-Tg-equg-T71086-Ag-1/ GM-Tg-equg-T71086-Ag-2 | Equine Complement factor H/CFH protein | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-T71086-Ag-1/ GM-Tg-hg-T71086-Ag-2;
GM-Tg-rg-T71086-Ag-1/ GM-Tg-rg-T71086-Ag-2;
GM-Tg-mg-T71086-Ag-1/ GM-Tg-mg-T71086-Ag-2; GM-Tg-cynog-T71086-Ag-1/ GM-Tg-cynog-T71086-Ag-2; GM-Tg-felg-T71086-Ag-1/ GM-Tg-felg-T71086-Ag-2; GM-Tg-cang-T71086-Ag-1/ GM-Tg-cang-T71086-Ag-2; GM-Tg-bovg-T71086-Ag-1/ GM-Tg-bovg-T71086-Ag-2; GM-Tg-equg-T71086-Ag-1/ GM-Tg-equg-T71086-Ag-2 |
| Products Name | Complement factor H/CFH protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | Complement factor H/CFH |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Complement factor H/CFH protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab
GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.