Explore Complement factor H/CFH gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
| Target ID |
GM-T71086
|
| Target Name |
Complement factor H/CFH
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3075
|
| Gene ID |
100051358 (Equus caballus), 12628 (Mus musculus), 3075 (Homo sapiens), 478952 (Canis lupus familiaris) 717346 (Macaca mulatta)
|
| Target Alternative Names |
AHUS1,AMBP1,ARMD4,ARMS1,CFH,CFH-L,CFHL3,Cfh,Complement factor H,FH,FHL1,H factor 1,HF,HF1,HF2,HUS,Mud-1,NOM,Sas-1,Sas1
|
| Uniprot Accession |
P06909,P08603
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
Dent disease, Diabetes type-2, Alzheimer's Disease
|
| Disease from KEGG |
Complement and coagulation cascades, Staphylococcus aureus infection
|
| Gene Ensembl |
ENSECAG00000011256, ENSMUSG00000026365, ENSG00000000971, ENSCAFG00845029192, ENSMMUG00000045497
|
Pre-made viral vector of Complement factor H/CFH cDNA Clones/ORF Plasmid
Complement factor H/CFH siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3075 | Pre-made Human CFH/FH/HF siRNA oligo Duplex | 3075 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12628 | Pre-made Mouse Cfh/NOM/Sas1 siRNA oligo Duplex | 12628 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo717346 | Pre-made Cynomolgus/Rhesus macaque CFH/CFH-L siRNA oligo Duplex | 717346 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478952 | Pre-made Dog/Canine CFH siRNA oligo Duplex | 478952 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051358 | Pre-made Equine/Horse CFH siRNA oligo Duplex | 100051358 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Complement factor H/CFH antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T71086-Ab | Human | Anti-Human Complement factor H/CFH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T71086-Ab | Mouse | Anti-Mouse Complement factor H/CFH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T71086-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Complement factor H/CFH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T71086-Ab | Dog/Canine | Anti-Dog/Canine Complement factor H/CFH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T71086-Ab | Equine/Horse | Anti-Equine/Horse Complement factor H/CFH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Complement factor H/CFH recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T71086-Ag | Human | Human Complement factor H/CFH recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T71086-Ag | Mouse | Mouse Complement factor H/CFH recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T71086-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Complement factor H/CFH recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T71086-Ag | Dog/Canine | Dog/Canine Complement factor H/CFH recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T71086-Ag | Equine/Horse | Equine/Horse Complement factor H/CFH recombinant protein | Mammalian cell | Detail |