Recombinant multi-species HRAS protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HRAS protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
The Alternative Names of target: C-BAS/HAS,C-H-RAS,C-HA-RAS1,CTLO,GTPase HRas,H-RAS,H-RASIDX,H-Ras,H-Ras-1,H-ras,HAMSV,HRAS,HRAS1,Ha-Ras,Ha-ras,Harvey-ras,Hras,Hras-1,Hras1,Kras2,RASH1,Transforming protein p21,c-H-ras,c-Ha-ras,c-rasHa,p21ras,ras

Target products collectionGo to HRAS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T71081-Ag-1/ GM-Tg-hg-T71081-Ag-2 Human HRAS protein Human
GM-Tg-rg-T71081-Ag-1/ GM-Tg-rg-T71081-Ag-2 Rat HRAS protein Rat
GM-Tg-mg-T71081-Ag-1/ GM-Tg-mg-T71081-Ag-2 Mouse HRAS protein Mouse
GM-Tg-cynog-T71081-Ag-1/ GM-Tg-cynog-T71081-Ag-2 Cynomolgus/Rhesus macaque HRAS protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T71081-Ag-1/ GM-Tg-felg-T71081-Ag-2 Feline HRAS protein Feline
GM-Tg-cang-T71081-Ag-1/ GM-Tg-cang-T71081-Ag-2 Canine HRAS protein Canine
GM-Tg-bovg-T71081-Ag-1/ GM-Tg-bovg-T71081-Ag-2 Bovine HRAS protein Bovine
GM-Tg-equg-T71081-Ag-1/ GM-Tg-equg-T71081-Ag-2 Equine HRAS protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T71081-Ag-1/ GM-Tg-hg-T71081-Ag-2; GM-Tg-rg-T71081-Ag-1/ GM-Tg-rg-T71081-Ag-2;
GM-Tg-mg-T71081-Ag-1/ GM-Tg-mg-T71081-Ag-2; GM-Tg-cynog-T71081-Ag-1/ GM-Tg-cynog-T71081-Ag-2;
GM-Tg-felg-T71081-Ag-1/ GM-Tg-felg-T71081-Ag-2; GM-Tg-cang-T71081-Ag-1/ GM-Tg-cang-T71081-Ag-2;
GM-Tg-bovg-T71081-Ag-1/ GM-Tg-bovg-T71081-Ag-2; GM-Tg-equg-T71081-Ag-1/ GM-Tg-equg-T71081-Ag-2
Products Name HRAS protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HRAS
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HRAS protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.