Recombinant multi-species SMARCA4/BRG1/BAF190A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMARCA4/BRG1/BAF190A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
The Alternative Names of target: ATP-dependent helicase SMARCA4,BAF190,BAF190A,BRG1,BRG1-associated factor 190A (BAF190A),Brg1,CSS4,HP1-BP72,MRD16,Mitotic growth and transcription activator,OTSC12,Protein BRG-1,Protein brahma homolog 1,RTPS2,SMARCA4,SNF2,SNF2-beta,SNF2L4,SNF2LB,SNF2beta,SW1/SNF,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4,SWI2,Smarca4,Transcription activator BRG1,b2b508.1Clo,b2b692Clo,brg-1,hSNF2b

Target products collectionGo to SMARCA4/BRG1/BAF190A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T69200-Ag-1/ GM-Tg-hg-T69200-Ag-2 Human SMARCA4/BRG1/BAF190A protein Human
GM-Tg-rg-T69200-Ag-1/ GM-Tg-rg-T69200-Ag-2 Rat SMARCA4/BRG1/BAF190A protein Rat
GM-Tg-mg-T69200-Ag-1/ GM-Tg-mg-T69200-Ag-2 Mouse SMARCA4/BRG1/BAF190A protein Mouse
GM-Tg-cynog-T69200-Ag-1/ GM-Tg-cynog-T69200-Ag-2 Cynomolgus/Rhesus macaque SMARCA4/BRG1/BAF190A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T69200-Ag-1/ GM-Tg-felg-T69200-Ag-2 Feline SMARCA4/BRG1/BAF190A protein Feline
GM-Tg-cang-T69200-Ag-1/ GM-Tg-cang-T69200-Ag-2 Canine SMARCA4/BRG1/BAF190A protein Canine
GM-Tg-bovg-T69200-Ag-1/ GM-Tg-bovg-T69200-Ag-2 Bovine SMARCA4/BRG1/BAF190A protein Bovine
GM-Tg-equg-T69200-Ag-1/ GM-Tg-equg-T69200-Ag-2 Equine SMARCA4/BRG1/BAF190A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T69200-Ag-1/ GM-Tg-hg-T69200-Ag-2; GM-Tg-rg-T69200-Ag-1/ GM-Tg-rg-T69200-Ag-2;
GM-Tg-mg-T69200-Ag-1/ GM-Tg-mg-T69200-Ag-2; GM-Tg-cynog-T69200-Ag-1/ GM-Tg-cynog-T69200-Ag-2;
GM-Tg-felg-T69200-Ag-1/ GM-Tg-felg-T69200-Ag-2; GM-Tg-cang-T69200-Ag-1/ GM-Tg-cang-T69200-Ag-2;
GM-Tg-bovg-T69200-Ag-1/ GM-Tg-bovg-T69200-Ag-2; GM-Tg-equg-T69200-Ag-1/ GM-Tg-equg-T69200-Ag-2
Products Name SMARCA4/BRG1/BAF190A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SMARCA4/BRG1/BAF190A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMARCA4/BRG1/BAF190A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.