Explore SMARCA4/BRG1/BAF190A gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
| Target ID |
GM-T69200
|
| Target Name |
SMARCA4/BRG1/BAF190A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6597
|
| Gene ID |
100054949 (Equus caballus), 101097046 (Felis catus), 171379 (Rattus norvegicus), 20586 (Mus musculus)
414274 (Bos taurus), 476710 (Canis lupus familiaris), 6597 (Homo sapiens), 716067 (Macaca mulatta)
|
| Target Alternative Names |
ATP-dependent helicase SMARCA4,BAF190,BAF190A,BRG1,BRG1-associated factor 190A (BAF190A),Brg1,CSS4,HP1-BP72,MRD16,Mitotic growth and transcription activator,OTSC12,Protein BRG-1,Protein brahma homolog 1,RTPS2,SMARCA4,SNF2,SNF2-beta,SNF2L4,SNF2LB,SNF2beta,SW1/SNF,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4,SWI2,Smarca4,Transcription activator BRG1,b2b508.1Clo,b2b692Clo,brg-1,hSNF2b
|
| Uniprot Accession |
Q8K1P7,Q3TKT4,A7Z019,P51532
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Hepatocellular carcinoma
|
| Gene Ensembl |
ENSECAG00000008334, ENSMUSG00000032187, ENSBTAG00000019220, ENSCAFG00845022085, ENSG00000127616, ENSMMUG00000012042
|
| Target Classification |
Epigenetic, Tumor-associated antigen (TAA)
|
SMARCA4/BRG1/BAF190A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6597 | Pre-made Human SMARCA4/BRG1/CSS4 siRNA oligo Duplex | 6597 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo171379 | Pre-made Rat Smarca4/brg-1 siRNA oligo Duplex | 171379 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20586 | Pre-made Mouse Smarca4/Brg1/BAF190A siRNA oligo Duplex | 20586 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716067 | Pre-made Cynomolgus/Rhesus macaque SMARCA4 siRNA oligo Duplex | 716067 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097046 | Pre-made Cat/Feline SMARCA4 siRNA oligo Duplex | 101097046 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476710 | Pre-made Dog/Canine SMARCA4 siRNA oligo Duplex | 476710 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo414274 | Pre-made Bovines/Cattle SMARCA4/BRG1/BAF190A siRNA oligo Duplex | 414274 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100054949 | Pre-made Equine/Horse SMARCA4 siRNA oligo Duplex | 100054949 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SMARCA4/BRG1/BAF190A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T69200-Ab | Human | Anti-Human SMARCA4/BRG1/BAF190A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T69200-Ab | Rat | Anti-Rat SMARCA4/BRG1/BAF190A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T69200-Ab | Mouse | Anti-Mouse SMARCA4/BRG1/BAF190A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T69200-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SMARCA4/BRG1/BAF190A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T69200-Ab | Cat/Feline | Anti-Cat/Feline SMARCA4/BRG1/BAF190A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T69200-Ab | Dog/Canine | Anti-Dog/Canine SMARCA4/BRG1/BAF190A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T69200-Ab | Bovines/Cattle | Anti-Bovines/Cattle SMARCA4/BRG1/BAF190A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T69200-Ab | Equine/Horse | Anti-Equine/Horse SMARCA4/BRG1/BAF190A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
SMARCA4/BRG1/BAF190A recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T69200-Ag | Human | Human SMARCA4/BRG1/BAF190A recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T69200-Ag | Rat | Rat SMARCA4/BRG1/BAF190A recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T69200-Ag | Mouse | Mouse SMARCA4/BRG1/BAF190A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T69200-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SMARCA4/BRG1/BAF190A recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T69200-Ag | Cat/Feline | Cat/Feline SMARCA4/BRG1/BAF190A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T69200-Ag | Dog/Canine | Dog/Canine SMARCA4/BRG1/BAF190A recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T69200-Ag | Bovines/Cattle | Bovines/Cattle SMARCA4/BRG1/BAF190A recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T69200-Ag | Equine/Horse | Equine/Horse SMARCA4/BRG1/BAF190A recombinant protein | Mammalian cell | Detail |
