Recombinant multi-species DNMT3B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DNMT3B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]
The Alternative Names of target: DNA (cytosine-5)-methyltransferase 3B,DNA methyltransferase HsaIIIB (DNA MTase HsaIIIB,DNMT3B,Dnmt3b,FSHD4,ICF,ICF1,M.HsaIIIB,M.HsaIIIB),MmuIIIB

Target products collectionGo to DNMT3B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T65501-Ag-1/ GM-Tg-hg-T65501-Ag-2 Human DNMT3B protein Human
GM-Tg-rg-T65501-Ag-1/ GM-Tg-rg-T65501-Ag-2 Rat DNMT3B protein Rat
GM-Tg-mg-T65501-Ag-1/ GM-Tg-mg-T65501-Ag-2 Mouse DNMT3B protein Mouse
GM-Tg-cynog-T65501-Ag-1/ GM-Tg-cynog-T65501-Ag-2 Cynomolgus/Rhesus macaque DNMT3B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T65501-Ag-1/ GM-Tg-felg-T65501-Ag-2 Feline DNMT3B protein Feline
GM-Tg-cang-T65501-Ag-1/ GM-Tg-cang-T65501-Ag-2 Canine DNMT3B protein Canine
GM-Tg-bovg-T65501-Ag-1/ GM-Tg-bovg-T65501-Ag-2 Bovine DNMT3B protein Bovine
GM-Tg-equg-T65501-Ag-1/ GM-Tg-equg-T65501-Ag-2 Equine DNMT3B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T65501-Ag-1/ GM-Tg-hg-T65501-Ag-2; GM-Tg-rg-T65501-Ag-1/ GM-Tg-rg-T65501-Ag-2;
GM-Tg-mg-T65501-Ag-1/ GM-Tg-mg-T65501-Ag-2; GM-Tg-cynog-T65501-Ag-1/ GM-Tg-cynog-T65501-Ag-2;
GM-Tg-felg-T65501-Ag-1/ GM-Tg-felg-T65501-Ag-2; GM-Tg-cang-T65501-Ag-1/ GM-Tg-cang-T65501-Ag-2;
GM-Tg-bovg-T65501-Ag-1/ GM-Tg-bovg-T65501-Ag-2; GM-Tg-equg-T65501-Ag-1/ GM-Tg-equg-T65501-Ag-2
Products Name DNMT3B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name DNMT3B
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DNMT3B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.