Recombinant multi-species Chk1/CHEK1/CHK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Chk1/CHEK1/CHK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
The Alternative Names of target: CHEK1,CHK1,CHK1 checkpoint homolog,Cell cycle checkpoint kinase,Checkpoint kinase-1,Chek1,Chk1,OZEMA21,Serine/threonine-protein kinase Chk1,rad27

Target products collectionGo to Chk1/CHEK1/CHK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T62449-Ag-1/ GM-Tg-hg-T62449-Ag-2 Human Chk1/CHEK1/CHK1 protein Human
GM-Tg-rg-T62449-Ag-1/ GM-Tg-rg-T62449-Ag-2 Rat Chk1/CHEK1/CHK1 protein Rat
GM-Tg-mg-T62449-Ag-1/ GM-Tg-mg-T62449-Ag-2 Mouse Chk1/CHEK1/CHK1 protein Mouse
GM-Tg-cynog-T62449-Ag-1/ GM-Tg-cynog-T62449-Ag-2 Cynomolgus/Rhesus macaque Chk1/CHEK1/CHK1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T62449-Ag-1/ GM-Tg-felg-T62449-Ag-2 Feline Chk1/CHEK1/CHK1 protein Feline
GM-Tg-cang-T62449-Ag-1/ GM-Tg-cang-T62449-Ag-2 Canine Chk1/CHEK1/CHK1 protein Canine
GM-Tg-bovg-T62449-Ag-1/ GM-Tg-bovg-T62449-Ag-2 Bovine Chk1/CHEK1/CHK1 protein Bovine
GM-Tg-equg-T62449-Ag-1/ GM-Tg-equg-T62449-Ag-2 Equine Chk1/CHEK1/CHK1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T62449-Ag-1/ GM-Tg-hg-T62449-Ag-2; GM-Tg-rg-T62449-Ag-1/ GM-Tg-rg-T62449-Ag-2;
GM-Tg-mg-T62449-Ag-1/ GM-Tg-mg-T62449-Ag-2; GM-Tg-cynog-T62449-Ag-1/ GM-Tg-cynog-T62449-Ag-2;
GM-Tg-felg-T62449-Ag-1/ GM-Tg-felg-T62449-Ag-2; GM-Tg-cang-T62449-Ag-1/ GM-Tg-cang-T62449-Ag-2;
GM-Tg-bovg-T62449-Ag-1/ GM-Tg-bovg-T62449-Ag-2; GM-Tg-equg-T62449-Ag-1/ GM-Tg-equg-T62449-Ag-2
Products Name Chk1/CHEK1/CHK1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Chk1/CHEK1/CHK1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Chk1/CHEK1/CHK1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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