Explore Chk1/CHEK1/CHK1 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
| Target ID |
GM-T62449
|
| Target Name |
Chk1/CHEK1/CHK1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1111
|
| Gene ID |
100064353 (Equus caballus), 101083365 (Felis catus), 1111 (Homo sapiens), 12649 (Mus musculus)
140583 (Rattus norvegicus), 513678 (Bos taurus), 609767 (Canis lupus familiaris), 713358 (Macaca mulatta)
|
| Target Alternative Names |
CHEK1,CHK1,CHK1 checkpoint homolog,Cell cycle checkpoint kinase,Checkpoint kinase-1,Chek1,Chk1,OZEMA21,Serine/threonine-protein kinase Chk1,rad27
|
| Uniprot Accession |
O14757,O35280,Q91ZN7
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
p53 signaling pathway, Cellular senescence, Human T-cell leukemia virus 1 infection
|
| Gene Ensembl |
ENSECAG00000045231, ENSG00000149554, ENSMUSG00000032113, ENSBTAG00000017582, ENSCAFG00845010598, ENSMMUG00000010010
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of Chk1/CHEK1/CHK1 cDNA Clones/ORF Plasmid
Chk1/CHEK1/CHK1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1111 | Pre-made Human CHEK1/CHK1/OZEMA21 siRNA oligo Duplex | 1111 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo140583 | Pre-made Rat Chek1 siRNA oligo Duplex | 140583 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12649 | Pre-made Mouse Chek1/Chk1/rad27 siRNA oligo Duplex | 12649 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo713358 | Pre-made Cynomolgus/Rhesus macaque CHEK1 siRNA oligo Duplex | 713358 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101083365 | Pre-made Cat/Feline CHEK1 siRNA oligo Duplex | 101083365 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609767 | Pre-made Dog/Canine CHEK1 siRNA oligo Duplex | 609767 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo513678 | Pre-made Bovines/Cattle CHEK1 siRNA oligo Duplex | 513678 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064353 | Pre-made Equine/Horse CHEK1 siRNA oligo Duplex | 100064353 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Chk1/CHEK1/CHK1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T62449-Ab | Human | Anti-Human Chk1/CHEK1/CHK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T62449-Ab | Rat | Anti-Rat Chk1/CHEK1/CHK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T62449-Ab | Mouse | Anti-Mouse Chk1/CHEK1/CHK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T62449-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Chk1/CHEK1/CHK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T62449-Ab | Cat/Feline | Anti-Cat/Feline Chk1/CHEK1/CHK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T62449-Ab | Dog/Canine | Anti-Dog/Canine Chk1/CHEK1/CHK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T62449-Ab | Bovines/Cattle | Anti-Bovines/Cattle Chk1/CHEK1/CHK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T62449-Ab | Equine/Horse | Anti-Equine/Horse Chk1/CHEK1/CHK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
Chk1/CHEK1/CHK1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T62449-Ag | Human | Human Chk1/CHEK1/CHK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T62449-Ag | Rat | Rat Chk1/CHEK1/CHK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T62449-Ag | Mouse | Mouse Chk1/CHEK1/CHK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T62449-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Chk1/CHEK1/CHK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T62449-Ag | Cat/Feline | Cat/Feline Chk1/CHEK1/CHK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T62449-Ag | Dog/Canine | Dog/Canine Chk1/CHEK1/CHK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T62449-Ag | Bovines/Cattle | Bovines/Cattle Chk1/CHEK1/CHK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T62449-Ag | Equine/Horse | Equine/Horse Chk1/CHEK1/CHK1 recombinant protein | Mammalian cell | Detail |
