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Recombinant multi-species SORD/Sorbitol dehydrogenase protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SORD/Sorbitol dehydrogenase protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
The Alternative Names of target: (R,HEL-S-95n,HMNR8,L-iditol 2-dehydrogenase,Polyol dehydrogenase,R)-butanediol dehydrogenase,RDH,Ribitol dehydrogenase (RDH),SDH,SORD,SORD1,SORDD,Sdh-1,Sdh1,Sodh-1,Sorbitol dehydrogenase,Sord,XDH,Xylitol dehydrogenase (XDH)
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MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T59445-Ag-1/ GM-Tg-hg-T59445-Ag-2 | Human SORD/Sorbitol dehydrogenase protein | Human |
| GM-Tg-rg-T59445-Ag-1/ GM-Tg-rg-T59445-Ag-2 | Rat SORD/Sorbitol dehydrogenase protein | Rat |
| GM-Tg-mg-T59445-Ag-1/ GM-Tg-mg-T59445-Ag-2 | Mouse SORD/Sorbitol dehydrogenase protein | Mouse |
| GM-Tg-cynog-T59445-Ag-1/ GM-Tg-cynog-T59445-Ag-2 | Cynomolgus/Rhesus macaque SORD/Sorbitol dehydrogenase protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T59445-Ag-1/ GM-Tg-felg-T59445-Ag-2 | Feline SORD/Sorbitol dehydrogenase protein | Feline |
| GM-Tg-cang-T59445-Ag-1/ GM-Tg-cang-T59445-Ag-2 | Canine SORD/Sorbitol dehydrogenase protein | Canine |
| GM-Tg-bovg-T59445-Ag-1/ GM-Tg-bovg-T59445-Ag-2 | Bovine SORD/Sorbitol dehydrogenase protein | Bovine |
| GM-Tg-equg-T59445-Ag-1/ GM-Tg-equg-T59445-Ag-2 | Equine SORD/Sorbitol dehydrogenase protein | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-T59445-Ag-1/ GM-Tg-hg-T59445-Ag-2;
GM-Tg-rg-T59445-Ag-1/ GM-Tg-rg-T59445-Ag-2;
GM-Tg-mg-T59445-Ag-1/ GM-Tg-mg-T59445-Ag-2; GM-Tg-cynog-T59445-Ag-1/ GM-Tg-cynog-T59445-Ag-2; GM-Tg-felg-T59445-Ag-1/ GM-Tg-felg-T59445-Ag-2; GM-Tg-cang-T59445-Ag-1/ GM-Tg-cang-T59445-Ag-2; GM-Tg-bovg-T59445-Ag-1/ GM-Tg-bovg-T59445-Ag-2; GM-Tg-equg-T59445-Ag-1/ GM-Tg-equg-T59445-Ag-2 |
| Products Name | SORD/Sorbitol dehydrogenase protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | SORD/Sorbitol dehydrogenase |
| Protein Sub-location | Introcelluar Protein |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SORD/Sorbitol dehydrogenase protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
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