Recombinant multi-species MAPK1/ERK2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MAPK1/ERK2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
The Alternative Names of target: 9030612K14Rik,ERK,ERK-2,ERK2,ERT1,Erk2,Extracellular signal-regulated kinase 2 (ERK-2),MAP kinase 1,MAP kinase isoform p42 (p42-MAPK),MAPK 1,MAPK 2),MAPK1,MAPK2,Mapk1,Mitogen-activated protein kinase 1,Mitogen-activated protein kinase 2 (MAP kinase 2,NS13,P42MAPK,PRKM1,PRKM2,Prkm1,p38,p40,p41,p41mapk,p42-MAPK,p42mapk

Target products collectionGo to MAPK1/ERK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T58970-Ag-1/ GM-Tg-hg-T58970-Ag-2 Human MAPK1/ERK2 protein Human
GM-Tg-rg-T58970-Ag-1/ GM-Tg-rg-T58970-Ag-2 Rat MAPK1/ERK2 protein Rat
GM-Tg-mg-T58970-Ag-1/ GM-Tg-mg-T58970-Ag-2 Mouse MAPK1/ERK2 protein Mouse
GM-Tg-cynog-T58970-Ag-1/ GM-Tg-cynog-T58970-Ag-2 Cynomolgus/Rhesus macaque MAPK1/ERK2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T58970-Ag-1/ GM-Tg-felg-T58970-Ag-2 Feline MAPK1/ERK2 protein Feline
GM-Tg-cang-T58970-Ag-1/ GM-Tg-cang-T58970-Ag-2 Canine MAPK1/ERK2 protein Canine
GM-Tg-bovg-T58970-Ag-1/ GM-Tg-bovg-T58970-Ag-2 Bovine MAPK1/ERK2 protein Bovine
GM-Tg-equg-T58970-Ag-1/ GM-Tg-equg-T58970-Ag-2 Equine MAPK1/ERK2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T58970-Ag-1/ GM-Tg-hg-T58970-Ag-2; GM-Tg-rg-T58970-Ag-1/ GM-Tg-rg-T58970-Ag-2;
GM-Tg-mg-T58970-Ag-1/ GM-Tg-mg-T58970-Ag-2; GM-Tg-cynog-T58970-Ag-1/ GM-Tg-cynog-T58970-Ag-2;
GM-Tg-felg-T58970-Ag-1/ GM-Tg-felg-T58970-Ag-2; GM-Tg-cang-T58970-Ag-1/ GM-Tg-cang-T58970-Ag-2;
GM-Tg-bovg-T58970-Ag-1/ GM-Tg-bovg-T58970-Ag-2; GM-Tg-equg-T58970-Ag-1/ GM-Tg-equg-T58970-Ag-2
Products Name MAPK1/ERK2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MAPK1/ERK2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MAPK1/ERK2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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