Recombinant multi-species KDM5B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine KDM5B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
The Alternative Names of target: 2010009J12Rik,2210016I17Rik,CT31,Cancer/testis antigen 31 (CT31),D1Ertd202e,Histone demethylase JARID1B,JARID1B,Jarid1b,Jumonji/ARID domain-containing protein 1B,KDM5B,Kdm5b,Lysine-specific demethylase 5B,MRT65,PLU-1,PLU1,PPP1R98,PUT1,Plu1,RBBP2H1A,RBP2-H1,RGD1565602,Rb-Bp2,Retinoblastoma-binding protein 2 homolog 1 (RBP2-H1),[histone H3]-trimethyl-L-lysine(4) demethylase 5B,mKIAA4034

Target products collectionGo to KDM5B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T56871-Ag-1/ GM-Tg-hg-T56871-Ag-2 Human KDM5B protein Human
GM-Tg-rg-T56871-Ag-1/ GM-Tg-rg-T56871-Ag-2 Rat KDM5B protein Rat
GM-Tg-mg-T56871-Ag-1/ GM-Tg-mg-T56871-Ag-2 Mouse KDM5B protein Mouse
GM-Tg-cynog-T56871-Ag-1/ GM-Tg-cynog-T56871-Ag-2 Cynomolgus/Rhesus macaque KDM5B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T56871-Ag-1/ GM-Tg-felg-T56871-Ag-2 Feline KDM5B protein Feline
GM-Tg-cang-T56871-Ag-1/ GM-Tg-cang-T56871-Ag-2 Canine KDM5B protein Canine
GM-Tg-bovg-T56871-Ag-1/ GM-Tg-bovg-T56871-Ag-2 Bovine KDM5B protein Bovine
GM-Tg-equg-T56871-Ag-1/ GM-Tg-equg-T56871-Ag-2 Equine KDM5B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T56871-Ag-1/ GM-Tg-hg-T56871-Ag-2; GM-Tg-rg-T56871-Ag-1/ GM-Tg-rg-T56871-Ag-2;
GM-Tg-mg-T56871-Ag-1/ GM-Tg-mg-T56871-Ag-2; GM-Tg-cynog-T56871-Ag-1/ GM-Tg-cynog-T56871-Ag-2;
GM-Tg-felg-T56871-Ag-1/ GM-Tg-felg-T56871-Ag-2; GM-Tg-cang-T56871-Ag-1/ GM-Tg-cang-T56871-Ag-2;
GM-Tg-bovg-T56871-Ag-1/ GM-Tg-bovg-T56871-Ag-2; GM-Tg-equg-T56871-Ag-1/ GM-Tg-equg-T56871-Ag-2
Products Name KDM5B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name KDM5B
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine KDM5B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.