Recombinant multi-species JMJD3/KDM6B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JMJD3/KDM6B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
The Alternative Names of target: 1700064E03Rik,JMJD3,JmjC domain-containing protein 3,Jmjd3,Jumonji domain-containing protein 3,KDM6B,Kdm6b,Lysine demethylase 6B,Lysine-specific demethylase 6B,NEDCFSA,NEDSST,[histone H3]-trimethyl-L-lysine(27) demethylase 6B

Target products collectionGo to JMJD3/KDM6B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T56057-Ag-1/ GM-Tg-hg-T56057-Ag-2 Human JMJD3/KDM6B protein Human
GM-Tg-rg-T56057-Ag-1/ GM-Tg-rg-T56057-Ag-2 Rat JMJD3/KDM6B protein Rat
GM-Tg-mg-T56057-Ag-1/ GM-Tg-mg-T56057-Ag-2 Mouse JMJD3/KDM6B protein Mouse
GM-Tg-cynog-T56057-Ag-1/ GM-Tg-cynog-T56057-Ag-2 Cynomolgus/Rhesus macaque JMJD3/KDM6B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T56057-Ag-1/ GM-Tg-felg-T56057-Ag-2 Feline JMJD3/KDM6B protein Feline
GM-Tg-cang-T56057-Ag-1/ GM-Tg-cang-T56057-Ag-2 Canine JMJD3/KDM6B protein Canine
GM-Tg-bovg-T56057-Ag-1/ GM-Tg-bovg-T56057-Ag-2 Bovine JMJD3/KDM6B protein Bovine
GM-Tg-equg-T56057-Ag-1/ GM-Tg-equg-T56057-Ag-2 Equine JMJD3/KDM6B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T56057-Ag-1/ GM-Tg-hg-T56057-Ag-2; GM-Tg-rg-T56057-Ag-1/ GM-Tg-rg-T56057-Ag-2;
GM-Tg-mg-T56057-Ag-1/ GM-Tg-mg-T56057-Ag-2; GM-Tg-cynog-T56057-Ag-1/ GM-Tg-cynog-T56057-Ag-2;
GM-Tg-felg-T56057-Ag-1/ GM-Tg-felg-T56057-Ag-2; GM-Tg-cang-T56057-Ag-1/ GM-Tg-cang-T56057-Ag-2;
GM-Tg-bovg-T56057-Ag-1/ GM-Tg-bovg-T56057-Ag-2; GM-Tg-equg-T56057-Ag-1/ GM-Tg-equg-T56057-Ag-2
Products Name JMJD3/KDM6B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name JMJD3/KDM6B
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JMJD3/KDM6B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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