Explore JMJD3/KDM6B gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
| Target ID |
GM-T56057
|
| Target Name |
JMJD3/KDM6B
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
23135
|
| Gene ID |
100073033 (Equus caballus), 100140276 (Bos taurus), 101100010 (Felis catus), 216850 (Mus musculus)
23135 (Homo sapiens), 363630 (Rattus norvegicus), 489481 (Canis lupus familiaris), 716348 (Macaca mulatta)
|
| Target Alternative Names |
1700064E03Rik,JMJD3,JmjC domain-containing protein 3,Jmjd3,Jumonji domain-containing protein 3,KDM6B,Kdm6b,Lysine demethylase 6B,Lysine-specific demethylase 6B,NEDCFSA,NEDSST,[histone H3]-trimethyl-L-lysine(27) demethylase 6B
|
| Uniprot Accession |
Q5NCY0,O15054
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000009828, ENSBTAG00000048062, ENSMUSG00000018476, ENSG00000132510, ENSCAFG00845025737, ENSMMUG00000008173
|
| Target Classification |
Epigenetic
|
Pre-made viral vector of JMJD3/KDM6B cDNA Clones/ORF Plasmid
JMJD3/KDM6B siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo23135 | Pre-made Human KDM6B/JMJD3/NEDSST siRNA oligo Duplex | 23135 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo363630 | Pre-made Rat Kdm6b/Jmjd3 siRNA oligo Duplex | 363630 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo216850 | Pre-made Mouse Kdm6b/Jmjd3/1700064E03Rik siRNA oligo Duplex | 216850 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716348 | Pre-made Cynomolgus/Rhesus macaque KDM6B siRNA oligo Duplex | 716348 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100010 | Pre-made Cat/Feline KDM6B siRNA oligo Duplex | 101100010 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489481 | Pre-made Dog/Canine KDM6B/JMJD3 siRNA oligo Duplex | 489481 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100140276 | Pre-made Bovines/Cattle KDM6B siRNA oligo Duplex | 100140276 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100073033 | Pre-made Equine/Horse KDM6B siRNA oligo Duplex | 100073033 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
JMJD3/KDM6B antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T56057-Ab | Human | Anti-Human JMJD3/KDM6B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T56057-Ab | Rat | Anti-Rat JMJD3/KDM6B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T56057-Ab | Mouse | Anti-Mouse JMJD3/KDM6B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T56057-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque JMJD3/KDM6B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T56057-Ab | Cat/Feline | Anti-Cat/Feline JMJD3/KDM6B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T56057-Ab | Dog/Canine | Anti-Dog/Canine JMJD3/KDM6B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T56057-Ab | Bovines/Cattle | Anti-Bovines/Cattle JMJD3/KDM6B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T56057-Ab | Equine/Horse | Anti-Equine/Horse JMJD3/KDM6B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
JMJD3/KDM6B recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T56057-Ag | Human | Human JMJD3/KDM6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T56057-Ag | Rat | Rat JMJD3/KDM6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T56057-Ag | Mouse | Mouse JMJD3/KDM6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T56057-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque JMJD3/KDM6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T56057-Ag | Cat/Feline | Cat/Feline JMJD3/KDM6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T56057-Ag | Dog/Canine | Dog/Canine JMJD3/KDM6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T56057-Ag | Bovines/Cattle | Bovines/Cattle JMJD3/KDM6B recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T56057-Ag | Equine/Horse | Equine/Horse JMJD3/KDM6B recombinant protein | Mammalian cell | Detail |
