Recombinant multi-species IRAK4/IRAK-4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IRAK4/IRAK-4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
The Alternative Names of target: IRAK4, IRAK-4,Interleukin-1 receptor-associated kinase 4,IRAK-4,Renal carcinoma antigen NY-REN-64,IPD1,IMD67,REN64,IRAK-4,NY-REN-64
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Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T55398-Ab-1/ GM-Tg-hg-T55398-Ab-2 | Human IRAK4/IRAK-4 protein | Human |
GM-Tg-rg-T55398-Ab-1/ GM-Tg-rg-T55398-Ab-2 | Rat IRAK4/IRAK-4 protein | Rat |
GM-Tg-mg-T55398-Ab-1/ GM-Tg-mg-T55398-Ab-2 | Mouse IRAK4/IRAK-4 protein | Mouse |
GM-Tg-cynog-T55398-Ab-1/ GM-Tg-cynog-T55398-Ab-2 | Cynomolgus/Rhesus macaque IRAK4/IRAK-4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T55398-Ab-1/ GM-Tg-felg-T55398-Ab-2 | Feline IRAK4/IRAK-4 protein | Feline |
GM-Tg-cang-T55398-Ab-1/ GM-Tg-cang-T55398-Ab-2 | Canine IRAK4/IRAK-4 protein | Canine |
GM-Tg-bovg-T55398-Ab-1/ GM-Tg-bovg-T55398-Ab-2 | Bovine IRAK4/IRAK-4 protein | Bovine |
GM-Tg-equg-T55398-Ab-1/ GM-Tg-equg-T55398-Ab-2 | Equine IRAK4/IRAK-4 protein | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. |
GM-Tg-hg-T55398-Ab-1/ GM-Tg-hg-T55398-Ab-2;
GM-Tg-rg-T55398-Ab-1/ GM-Tg-rg-T55398-Ab-2;
GM-Tg-mg-T55398-Ab-1/ GM-Tg-mg-T55398-Ab-2; GM-Tg-cynog-T55398-Ab-1/ GM-Tg-cynog-T55398-Ab-2; GM-Tg-felg-T55398-Ab-1/ GM-Tg-felg-T55398-Ab-2; GM-Tg-cang-T55398-Ab-1/ GM-Tg-cang-T55398-Ab-2; GM-Tg-bovg-T55398-Ab-1/ GM-Tg-bovg-T55398-Ab-2; GM-Tg-equg-T55398-Ab-1/ GM-Tg-equg-T55398-Ab-2 |
Products Name | IRAK4/IRAK-4 protein |
Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
Target Name | IRAK4/IRAK-4 |
Protein Sub-location | Introcelluar Protein |
Isotypes | Recombinant protein |
Expression platform | Mammalian cell |
Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
Tag | His |
Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IRAK4/IRAK-4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab
GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.