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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
| Target ID |
GM-T55398
|
| Target Name |
IRAK4/IRAK-4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
51135
|
| Gene ID |
100054848 (Equus caballus), 101100225 (Felis catus), 266632 (Mus musculus), 300177 (Rattus norvegicus)
486601 (Canis lupus familiaris), 51135 (Homo sapiens), 533692 (Bos taurus), 700568 (Macaca mulatta)
|
| Target Alternative Names |
IRAK4,Irak4,IRAK-4,NY-REN-64,8430405M07Rik,9330209D03Rik,IPD1,IMD67,REN64
|
| Uniprot Accession |
Q8R4K2,Q9NWZ3,Q1RMT8
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
|
| Disease from KEGG |
MAPK signaling pathway, NF-kappa B signaling pathway, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Alcoholic liver disease, Pathogenic Escherichia coli infection, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease, Toxoplasmosis, Tuberculosis, Hepatitis B, Measles, Influenza A, Epstein-Barr virus infection, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000014866, ENSMUSG00000059883, ENSCAFG00845029210, ENSG00000198001, ENSBTAG00000021105, ENSMMUG00000000204
|
| Target Classification |
Kinase, Checkpoint-Immuno Oncology
|
Pre-made viral vector of IRAK4/IRAK-4 cDNA Clones/ORF Plasmid
IRAK4/IRAK-4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo51135 | Pre-made Human IRAK4/IPD1/IMD67 siRNA oligo Duplex | 51135 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo300177 | Pre-made Rat Irak4 siRNA oligo Duplex | 300177 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo266632 | Pre-made Mouse Irak4/IRAK-4/NY-REN-64 siRNA oligo Duplex | 266632 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo700568 | Pre-made Cynomolgus/Rhesus macaque IRAK4 siRNA oligo Duplex | 700568 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100225 | Pre-made Cat/Feline IRAK4 siRNA oligo Duplex | 101100225 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486601 | Pre-made Dog/Canine IRAK4 siRNA oligo Duplex | 486601 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo533692 | Pre-made Bovines/Cattle IRAK4/IRAK-4 siRNA oligo Duplex | 533692 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100054848 | Pre-made Equine/Horse IRAK4 siRNA oligo Duplex | 100054848 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IRAK4/IRAK-4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T55398-Ab | Human | Anti-Human IRAK4/IRAK-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T55398-Ab | Rat | Anti-Rat IRAK4/IRAK-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T55398-Ab | Mouse | Anti-Mouse IRAK4/IRAK-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T55398-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IRAK4/IRAK-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T55398-Ab | Cat/Feline | Anti-Cat/Feline IRAK4/IRAK-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T55398-Ab | Dog/Canine | Anti-Dog/Canine IRAK4/IRAK-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T55398-Ab | Bovines/Cattle | Anti-Bovines/Cattle IRAK4/IRAK-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T55398-Ab | Equine/Horse | Anti-Equine/Horse IRAK4/IRAK-4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
IRAK4/IRAK-4 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T55398-Ag | Human | Human IRAK4/IRAK-4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T55398-Ag | Rat | Rat IRAK4/IRAK-4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T55398-Ag | Mouse | Mouse IRAK4/IRAK-4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T55398-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IRAK4/IRAK-4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T55398-Ag | Cat/Feline | Cat/Feline IRAK4/IRAK-4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T55398-Ag | Dog/Canine | Dog/Canine IRAK4/IRAK-4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T55398-Ag | Bovines/Cattle | Bovines/Cattle IRAK4/IRAK-4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T55398-Ag | Equine/Horse | Equine/Horse IRAK4/IRAK-4 recombinant protein | Mammalian cell | Detail |
