Recombinant multi-species UNC13B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine UNC13B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]
The Alternative Names of target: MUNC13,Munc13-1,Munc13-2,Munc13-2 (munc13),Protein unc-13 homolog B,UNC13,UNC13B,Unc13a,Unc13b,Unc13h1,Unc13h2,munc13-2

Target products collectionGo to UNC13B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T53070-Ag-1/ GM-Tg-hg-T53070-Ag-2 Human UNC13B protein Human
GM-Tg-rg-T53070-Ag-1/ GM-Tg-rg-T53070-Ag-2 Rat UNC13B protein Rat
GM-Tg-mg-T53070-Ag-1/ GM-Tg-mg-T53070-Ag-2 Mouse UNC13B protein Mouse
GM-Tg-cynog-T53070-Ag-1/ GM-Tg-cynog-T53070-Ag-2 Cynomolgus/Rhesus macaque UNC13B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T53070-Ag-1/ GM-Tg-felg-T53070-Ag-2 Feline UNC13B protein Feline
GM-Tg-cang-T53070-Ag-1/ GM-Tg-cang-T53070-Ag-2 Canine UNC13B protein Canine
GM-Tg-bovg-T53070-Ag-1/ GM-Tg-bovg-T53070-Ag-2 Bovine UNC13B protein Bovine
GM-Tg-equg-T53070-Ag-1/ GM-Tg-equg-T53070-Ag-2 Equine UNC13B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T53070-Ag-1/ GM-Tg-hg-T53070-Ag-2; GM-Tg-rg-T53070-Ag-1/ GM-Tg-rg-T53070-Ag-2;
GM-Tg-mg-T53070-Ag-1/ GM-Tg-mg-T53070-Ag-2; GM-Tg-cynog-T53070-Ag-1/ GM-Tg-cynog-T53070-Ag-2;
GM-Tg-felg-T53070-Ag-1/ GM-Tg-felg-T53070-Ag-2; GM-Tg-cang-T53070-Ag-1/ GM-Tg-cang-T53070-Ag-2;
GM-Tg-bovg-T53070-Ag-1/ GM-Tg-bovg-T53070-Ag-2; GM-Tg-equg-T53070-Ag-1/ GM-Tg-equg-T53070-Ag-2
Products Name UNC13B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name UNC13B
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine UNC13B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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