Explore UNC13B gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T53070
|
| Target Name |
UNC13B
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10497
|
| Gene ID |
100055666 (Equus caballus), 100683511 (Canis lupus familiaris), 101089655 (Felis catus), 10497 (Homo sapiens)
22249 (Mus musculus), 530692 (Bos taurus), 64830 (Rattus norvegicus), 697393 (Macaca mulatta)
|
| Target Alternative Names |
MUNC13,Munc13-1,Munc13-2,Munc13-2 (munc13),Protein unc-13 homolog B,UNC13,UNC13B,Unc13a,Unc13b,Unc13h1,Unc13h2,munc13-2
|
| Uniprot Accession |
O14795,Q9Z1N9,Q62769
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSECAG00000019234, ENSCAFG00845006572, ENSG00000198722, ENSMUSG00000028456, ENSBTAG00000011397, ENSMMUG00000016308
|
UNC13B siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10497 | Pre-made Human UNC13B/UNC13/MUNC13 siRNA oligo Duplex | 10497 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64830 | Pre-made Rat Unc13b/Unc13h2/Munc13-2 siRNA oligo Duplex | 64830 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22249 | Pre-made Mouse Unc13b/Unc13a/Unc13h1 siRNA oligo Duplex | 22249 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697393 | Pre-made Cynomolgus/Rhesus macaque UNC13B siRNA oligo Duplex | 697393 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089655 | Pre-made Cat/Feline UNC13B siRNA oligo Duplex | 101089655 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100683511 | Pre-made Dog/Canine UNC13B siRNA oligo Duplex | 100683511 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo530692 | Pre-made Bovines/Cattle UNC13B siRNA oligo Duplex | 530692 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055666 | Pre-made Equine/Horse UNC13B siRNA oligo Duplex | 100055666 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
UNC13B antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T53070-Ab | Human | Anti-Human UNC13B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T53070-Ab | Rat | Anti-Rat UNC13B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T53070-Ab | Mouse | Anti-Mouse UNC13B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T53070-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque UNC13B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T53070-Ab | Cat/Feline | Anti-Cat/Feline UNC13B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T53070-Ab | Dog/Canine | Anti-Dog/Canine UNC13B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T53070-Ab | Bovines/Cattle | Anti-Bovines/Cattle UNC13B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T53070-Ab | Equine/Horse | Anti-Equine/Horse UNC13B monoclonal antibody | mab | Therapeutics Target antibody | Detail |
UNC13B recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T53070-Ag | Human | Human UNC13B recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T53070-Ag | Rat | Rat UNC13B recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T53070-Ag | Mouse | Mouse UNC13B recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T53070-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque UNC13B recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T53070-Ag | Cat/Feline | Cat/Feline UNC13B recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T53070-Ag | Dog/Canine | Dog/Canine UNC13B recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T53070-Ag | Bovines/Cattle | Bovines/Cattle UNC13B recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T53070-Ag | Equine/Horse | Equine/Horse UNC13B recombinant protein | Mammalian cell | Detail |
