Recombinant multi-species NR1H3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR1H3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
The Alternative Names of target: LXR,LXR-a,LXRA,LXRalpha,Liver X receptor alpha,NR1H3,Nr1h3,Nuclear receptor subfamily 1 group H member 3,Oxysterols receptor LXR-alpha,RLD-1,RLD1,Unr1

Target products collectionGo to NR1H3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T52297-Ag-1/ GM-Tg-hg-T52297-Ag-2 Human NR1H3 protein Human
GM-Tg-rg-T52297-Ag-1/ GM-Tg-rg-T52297-Ag-2 Rat NR1H3 protein Rat
GM-Tg-mg-T52297-Ag-1/ GM-Tg-mg-T52297-Ag-2 Mouse NR1H3 protein Mouse
GM-Tg-cynog-T52297-Ag-1/ GM-Tg-cynog-T52297-Ag-2 Cynomolgus/Rhesus macaque NR1H3 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T52297-Ag-1/ GM-Tg-felg-T52297-Ag-2 Feline NR1H3 protein Feline
GM-Tg-cang-T52297-Ag-1/ GM-Tg-cang-T52297-Ag-2 Canine NR1H3 protein Canine
GM-Tg-bovg-T52297-Ag-1/ GM-Tg-bovg-T52297-Ag-2 Bovine NR1H3 protein Bovine
GM-Tg-equg-T52297-Ag-1/ GM-Tg-equg-T52297-Ag-2 Equine NR1H3 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T52297-Ag-1/ GM-Tg-hg-T52297-Ag-2; GM-Tg-rg-T52297-Ag-1/ GM-Tg-rg-T52297-Ag-2;
GM-Tg-mg-T52297-Ag-1/ GM-Tg-mg-T52297-Ag-2; GM-Tg-cynog-T52297-Ag-1/ GM-Tg-cynog-T52297-Ag-2;
GM-Tg-felg-T52297-Ag-1/ GM-Tg-felg-T52297-Ag-2; GM-Tg-cang-T52297-Ag-1/ GM-Tg-cang-T52297-Ag-2;
GM-Tg-bovg-T52297-Ag-1/ GM-Tg-bovg-T52297-Ag-2; GM-Tg-equg-T52297-Ag-1/ GM-Tg-equg-T52297-Ag-2
Products Name NR1H3 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name NR1H3
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR1H3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.