NR1H3 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore NR1H3 gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Target ID GM-T52297
Target Name NR1H3
Gene Group ldentifer
(Target Gene ID in Homo species)
10062
Gene ID 100051253 (Equus caballus), 10062 (Homo sapiens), 101092889 (Felis catus), 22259 (Mus musculus)
483625 (Canis lupus familiaris), 507176 (Bos taurus), 58852 (Rattus norvegicus), 713679 (Macaca mulatta)
Target Alternative Names LXR,LXR-a,LXRA,LXRalpha,Liver X receptor alpha,NR1H3,Nr1h3,Nuclear receptor subfamily 1 group H member 3,Oxysterols receptor LXR-alpha,RLD-1,RLD1,Unr1
Uniprot Accession Q13133,Q9Z0Y9,Q5E9B6,Q62685
Protein Sub-location Introcelluar Protein
Category Therapeutics Target, Immuno-oncology Target
Disease from KEGG PPAR signaling pathway, Insulin resistance, Hepatitis C
Gene Ensembl ENSECAG00000015726, ENSG00000025434, ENSMUSG00000002108, ENSCAFG00845024090, ENSBTAG00000010681, ENSMMUG00000015598
Target Classification Nuclear Receptors, Checkpoint-Immuno Oncology


Pre-made viral vector of NR1H3 cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLP001408Human NR1H3/LXR-a/LXRA Lentivirus plasmidNM_00113010210062HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMLV002334Human NR1H3/LXR-a/LXRA Lentivirus plasmidNM_005693.410062HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMLV002340Human NR1H3/LXR-a/LXRA Lentivirus plasmidNM_005693.410062HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLP001408Human NR1H3/LXR-a/LXRA Lentivirus particleNM_00113010210062HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLV002334Human NR1H3/LXR-a/LXRA Lentivirus particleNM_005693.410062HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLV002340Human NR1H3/LXR-a/LXRA Lentivirus particleNM_005693.410062HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
pGMLPm001526Mouse Nr1h3/AU018371/LXR Lentivirus plasmidNM_00117773022259MouseLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLPm001526Mouse Nr1h3/AU018371/LXR Lentivirus particleNM_00117773022259MouseLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail


NR1H3 siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo10062Pre-made Human NR1H3/LXRA/LXR-a siRNA oligo Duplex10062HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo58852Pre-made Rat Nr1h3/LXRalpha siRNA oligo Duplex58852RatIn-vitro grade; in-vivo gradeDetail
pGMoligo22259Pre-made Mouse Nr1h3/LXR/RLD1 siRNA oligo Duplex22259MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo713679Pre-made Cynomolgus/Rhesus macaque NR1H3 siRNA oligo Duplex713679Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo101092889Pre-made Cat/Feline NR1H3 siRNA oligo Duplex101092889Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo483625Pre-made Dog/Canine NR1H3 siRNA oligo Duplex483625Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo507176Pre-made Bovines/Cattle NR1H3/LXRalpha siRNA oligo Duplex507176Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100051253Pre-made Equine/Horse NR1H3 siRNA oligo Duplex100051253Equine/HorseIn-vitro grade; in-vivo gradeDetail


NR1H3 antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T52297-AbHumanAnti-Human NR1H3 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-rg-T52297-AbRatAnti-Rat NR1H3 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-mg-T52297-AbMouseAnti-Mouse NR1H3 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cynog-T52297-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque NR1H3 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-felg-T52297-AbCat/FelineAnti-Cat/Feline NR1H3 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cang-T52297-AbDog/CanineAnti-Dog/Canine NR1H3 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-bovg-T52297-AbBovines/CattleAnti-Bovines/Cattle NR1H3 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-equg-T52297-AbEquine/HorseAnti-Equine/Horse NR1H3 monoclonal antibodymabTherapeutics Target antibodyDetail


NR1H3 recombinant protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T52297-AgHumanHuman NR1H3 recombinant proteinMammalian cellDetail
GM-Tg-rg-T52297-AgRatRat NR1H3 recombinant proteinMammalian cellDetail
GM-Tg-mg-T52297-AgMouseMouse NR1H3 recombinant proteinMammalian cellDetail
GM-Tg-cynog-T52297-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque NR1H3 recombinant proteinMammalian cellDetail
GM-Tg-felg-T52297-AgCat/FelineCat/Feline NR1H3 recombinant proteinMammalian cellDetail
GM-Tg-cang-T52297-AgDog/CanineDog/Canine NR1H3 recombinant proteinMammalian cellDetail
GM-Tg-bovg-T52297-AgBovines/CattleBovines/Cattle NR1H3 recombinant proteinMammalian cellDetail
GM-Tg-equg-T52297-AgEquine/HorseEquine/Horse NR1H3 recombinant proteinMammalian cellDetail