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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
| Target ID |
GM-T52297
|
| Target Name |
NR1H3
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
10062
|
| Gene ID |
100051253 (Equus caballus), 10062 (Homo sapiens), 101092889 (Felis catus), 22259 (Mus musculus) 483625 (Canis lupus familiaris), 507176 (Bos taurus), 58852 (Rattus norvegicus), 713679 (Macaca mulatta)
|
| Target Alternative Names |
LXR,LXR-a,LXRA,LXRalpha,Liver X receptor alpha,NR1H3,Nr1h3,Nuclear receptor subfamily 1 group H member 3,Oxysterols receptor LXR-alpha,RLD-1,RLD1,Unr1
|
| Uniprot Accession |
Q13133,Q9Z0Y9,Q5E9B6,Q62685
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease from KEGG |
PPAR signaling pathway, Insulin resistance, Hepatitis C
|
| Gene Ensembl |
ENSECAG00000015726, ENSG00000025434, ENSMUSG00000002108, ENSCAFG00845024090, ENSBTAG00000010681, ENSMMUG00000015598
|
| Target Classification |
Nuclear Receptors, Checkpoint-Immuno Oncology
|
Pre-made viral vector of NR1H3 cDNA Clones/ORF Plasmid
NR1H3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10062 | Pre-made Human NR1H3/LXRA/LXR-a siRNA oligo Duplex | 10062 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo58852 | Pre-made Rat Nr1h3/LXRalpha siRNA oligo Duplex | 58852 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22259 | Pre-made Mouse Nr1h3/LXR/RLD1 siRNA oligo Duplex | 22259 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo713679 | Pre-made Cynomolgus/Rhesus macaque NR1H3 siRNA oligo Duplex | 713679 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092889 | Pre-made Cat/Feline NR1H3 siRNA oligo Duplex | 101092889 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo483625 | Pre-made Dog/Canine NR1H3 siRNA oligo Duplex | 483625 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo507176 | Pre-made Bovines/Cattle NR1H3/LXRalpha siRNA oligo Duplex | 507176 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051253 | Pre-made Equine/Horse NR1H3 siRNA oligo Duplex | 100051253 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NR1H3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T52297-Ab | Human | Anti-Human NR1H3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T52297-Ab | Rat | Anti-Rat NR1H3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T52297-Ab | Mouse | Anti-Mouse NR1H3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T52297-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NR1H3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T52297-Ab | Cat/Feline | Anti-Cat/Feline NR1H3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T52297-Ab | Dog/Canine | Anti-Dog/Canine NR1H3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T52297-Ab | Bovines/Cattle | Anti-Bovines/Cattle NR1H3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T52297-Ab | Equine/Horse | Anti-Equine/Horse NR1H3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
NR1H3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T52297-Ag | Human | Human NR1H3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T52297-Ag | Rat | Rat NR1H3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T52297-Ag | Mouse | Mouse NR1H3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T52297-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NR1H3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T52297-Ag | Cat/Feline | Cat/Feline NR1H3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T52297-Ag | Dog/Canine | Dog/Canine NR1H3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T52297-Ag | Bovines/Cattle | Bovines/Cattle NR1H3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T52297-Ag | Equine/Horse | Equine/Horse NR1H3 recombinant protein | Mammalian cell | Detail |