Recombinant multi-species ROCK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ROCK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
The Alternative Names of target: 1110055K06Rik,P160ROCK,P160Rock,ROCK-I,ROCK1,Renal carcinoma antigen NY-REN-35,Rho-associated,Rho-associated protein kinase 1,Rock-I,Rock1,coiled-coil-containing protein kinase 1,coiled-coil-containing protein kinase I (ROCK-I),p160 ROCK-1 (p160ROCK),p160ROCK

Target products collectionGo to ROCK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T51282-Ag-1/ GM-Tg-hg-T51282-Ag-2 Human ROCK1 protein Human
GM-Tg-rg-T51282-Ag-1/ GM-Tg-rg-T51282-Ag-2 Rat ROCK1 protein Rat
GM-Tg-mg-T51282-Ag-1/ GM-Tg-mg-T51282-Ag-2 Mouse ROCK1 protein Mouse
GM-Tg-cynog-T51282-Ag-1/ GM-Tg-cynog-T51282-Ag-2 Cynomolgus/Rhesus macaque ROCK1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T51282-Ag-1/ GM-Tg-felg-T51282-Ag-2 Feline ROCK1 protein Feline
GM-Tg-cang-T51282-Ag-1/ GM-Tg-cang-T51282-Ag-2 Canine ROCK1 protein Canine
GM-Tg-bovg-T51282-Ag-1/ GM-Tg-bovg-T51282-Ag-2 Bovine ROCK1 protein Bovine
GM-Tg-equg-T51282-Ag-1/ GM-Tg-equg-T51282-Ag-2 Equine ROCK1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T51282-Ag-1/ GM-Tg-hg-T51282-Ag-2; GM-Tg-rg-T51282-Ag-1/ GM-Tg-rg-T51282-Ag-2;
GM-Tg-mg-T51282-Ag-1/ GM-Tg-mg-T51282-Ag-2; GM-Tg-cynog-T51282-Ag-1/ GM-Tg-cynog-T51282-Ag-2;
GM-Tg-felg-T51282-Ag-1/ GM-Tg-felg-T51282-Ag-2; GM-Tg-cang-T51282-Ag-1/ GM-Tg-cang-T51282-Ag-2;
GM-Tg-bovg-T51282-Ag-1/ GM-Tg-bovg-T51282-Ag-2; GM-Tg-equg-T51282-Ag-1/ GM-Tg-equg-T51282-Ag-2
Products Name ROCK1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ROCK1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ROCK1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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