Explore ROCK1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
| Target ID |
GM-T51282
|
| Target Name |
ROCK1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6093
|
| Gene ID |
100034056 (Equus caballus), 101092552 (Felis catus), 19877 (Mus musculus), 480181 (Canis lupus familiaris)
6093 (Homo sapiens), 698223 (Macaca mulatta), 785911 (Bos taurus), 81762 (Rattus norvegicus)
|
| Target Alternative Names |
1110055K06Rik,P160ROCK,P160Rock,ROCK-I,ROCK1,Renal carcinoma antigen NY-REN-35,Rho-associated,Rho-associated protein kinase 1,Rock-I,Rock1,coiled-coil-containing protein kinase 1,coiled-coil-containing protein kinase I (ROCK-I),p160 ROCK-1 (p160ROCK),p160ROCK
|
| Uniprot Accession |
P70335,Q13464,Q8MIT6,Q63644
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, TGF-beta signaling pathway, Axon guidance, Focal adhesion, Tight junction, Platelet activation, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Yersinia infection, Human cytomegalovirus infection, Pathways in cancer, Proteoglycans in cancer
|
| Gene Ensembl |
ENSECAG00000021002, ENSMUSG00000024290, ENSCAFG00845001454, ENSG00000067900, ENSMMUG00000004656, ENSBTAG00000008403
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of ROCK1 cDNA Clones/ORF Plasmid
ROCK1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6093 | Pre-made Human ROCK1/ROCK-I/P160ROCK siRNA oligo Duplex | 6093 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81762 | Pre-made Rat Rock1/ROCK-I/P160Rock siRNA oligo Duplex | 81762 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19877 | Pre-made Mouse Rock1/Rock-I/1110055K06Rik siRNA oligo Duplex | 19877 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698223 | Pre-made Cynomolgus/Rhesus macaque ROCK1 siRNA oligo Duplex | 698223 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092552 | Pre-made Cat/Feline ROCK1 siRNA oligo Duplex | 101092552 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo480181 | Pre-made Dog/Canine ROCK1 siRNA oligo Duplex | 480181 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo785911 | Pre-made Bovines/Cattle ROCK1/ROCK-I/p160ROCK siRNA oligo Duplex | 785911 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034056 | Pre-made Equine/Horse ROCK1 siRNA oligo Duplex | 100034056 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ROCK1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T51282-Ab | Human | Anti-Human ROCK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T51282-Ab | Rat | Anti-Rat ROCK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T51282-Ab | Mouse | Anti-Mouse ROCK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T51282-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ROCK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T51282-Ab | Cat/Feline | Anti-Cat/Feline ROCK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T51282-Ab | Dog/Canine | Anti-Dog/Canine ROCK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T51282-Ab | Bovines/Cattle | Anti-Bovines/Cattle ROCK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T51282-Ab | Equine/Horse | Anti-Equine/Horse ROCK1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
ROCK1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T51282-Ag | Human | Human ROCK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T51282-Ag | Rat | Rat ROCK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T51282-Ag | Mouse | Mouse ROCK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T51282-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ROCK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T51282-Ag | Cat/Feline | Cat/Feline ROCK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T51282-Ag | Dog/Canine | Dog/Canine ROCK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T51282-Ag | Bovines/Cattle | Bovines/Cattle ROCK1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T51282-Ag | Equine/Horse | Equine/Horse ROCK1 recombinant protein | Mammalian cell | Detail |
