Recombinant multi-species WRN protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine WRN protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
The Alternative Names of target: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN,DNA helicase,RECQ3,RECQL2,RECQL3,RGD1564788,RecQ protein-like 2,RecQ-like type 3,WRN,Werner syndrome protein,Wrn

Target products collectionGo to WRN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T47583-Ag-1/ GM-Tg-hg-T47583-Ag-2 Human WRN protein Human
GM-Tg-rg-T47583-Ag-1/ GM-Tg-rg-T47583-Ag-2 Rat WRN protein Rat
GM-Tg-mg-T47583-Ag-1/ GM-Tg-mg-T47583-Ag-2 Mouse WRN protein Mouse
GM-Tg-cynog-T47583-Ag-1/ GM-Tg-cynog-T47583-Ag-2 Cynomolgus/Rhesus macaque WRN protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T47583-Ag-1/ GM-Tg-felg-T47583-Ag-2 Feline WRN protein Feline
GM-Tg-cang-T47583-Ag-1/ GM-Tg-cang-T47583-Ag-2 Canine WRN protein Canine
GM-Tg-bovg-T47583-Ag-1/ GM-Tg-bovg-T47583-Ag-2 Bovine WRN protein Bovine
GM-Tg-equg-T47583-Ag-1/ GM-Tg-equg-T47583-Ag-2 Equine WRN protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T47583-Ag-1/ GM-Tg-hg-T47583-Ag-2; GM-Tg-rg-T47583-Ag-1/ GM-Tg-rg-T47583-Ag-2;
GM-Tg-mg-T47583-Ag-1/ GM-Tg-mg-T47583-Ag-2; GM-Tg-cynog-T47583-Ag-1/ GM-Tg-cynog-T47583-Ag-2;
GM-Tg-felg-T47583-Ag-1/ GM-Tg-felg-T47583-Ag-2; GM-Tg-cang-T47583-Ag-1/ GM-Tg-cang-T47583-Ag-2;
GM-Tg-bovg-T47583-Ag-1/ GM-Tg-bovg-T47583-Ag-2; GM-Tg-equg-T47583-Ag-1/ GM-Tg-equg-T47583-Ag-2
Products Name WRN protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name WRN
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine WRN protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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