Explore WRN gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T47583
|
| Target Name |
WRN
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7486
|
| Gene ID |
100062021 (Equus caballus), 101095574 (Felis catus), 22427 (Mus musculus), 290805 (Rattus norvegicus)
493997 (Canis lupus familiaris), 505061 (Bos taurus), 695678 (Macaca mulatta), 7486 (Homo sapiens)
|
| Target Alternative Names |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN,DNA helicase,RECQ3,RECQL2,RECQL3,RGD1564788,RecQ protein-like 2,RecQ-like type 3,WRN,Werner syndrome protein,Wrn
|
| Uniprot Accession |
O09053,Q14191
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000000110, ENSMUSG00000031583, ENSCAFG00845015638, ENSBTAG00000021592, ENSMMUG00000022655, ENSG00000165392
|
| Target Classification |
Tumor-associated antigen (TAA)
|
WRN siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7486 | Pre-made Human WRN/RECQ3/RECQL2 siRNA oligo Duplex | 7486 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo290805 | Pre-made Rat Wrn/RGD1564788 siRNA oligo Duplex | 290805 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22427 | Pre-made Mouse Wrn siRNA oligo Duplex | 22427 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695678 | Pre-made Cynomolgus/Rhesus macaque WRN siRNA oligo Duplex | 695678 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095574 | Pre-made Cat/Feline WRN siRNA oligo Duplex | 101095574 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493997 | Pre-made Dog/Canine WRN siRNA oligo Duplex | 493997 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo505061 | Pre-made Bovines/Cattle WRN siRNA oligo Duplex | 505061 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100062021 | Pre-made Equine/Horse WRN siRNA oligo Duplex | 100062021 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
WRN antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T47583-Ab | Human | Anti-Human WRN monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T47583-Ab | Rat | Anti-Rat WRN monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T47583-Ab | Mouse | Anti-Mouse WRN monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T47583-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque WRN monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T47583-Ab | Cat/Feline | Anti-Cat/Feline WRN monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T47583-Ab | Dog/Canine | Anti-Dog/Canine WRN monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T47583-Ab | Bovines/Cattle | Anti-Bovines/Cattle WRN monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T47583-Ab | Equine/Horse | Anti-Equine/Horse WRN monoclonal antibody | mab | Therapeutics Target antibody | Detail |
WRN recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T47583-Ag | Human | Human WRN recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T47583-Ag | Rat | Rat WRN recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T47583-Ag | Mouse | Mouse WRN recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T47583-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque WRN recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T47583-Ag | Cat/Feline | Cat/Feline WRN recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T47583-Ag | Dog/Canine | Dog/Canine WRN recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T47583-Ag | Bovines/Cattle | Bovines/Cattle WRN recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T47583-Ag | Equine/Horse | Equine/Horse WRN recombinant protein | Mammalian cell | Detail |
