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Recombinant multi-species t-Plasminogen activator/tPA/PLAT protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine t-Plasminogen activator/tPA/PLAT protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
The Alternative Names of target: t-Plasminogen activator, tPA, PLAT,Tissue-type plasminogen activator,t-PA, t-plasminogen activator, tPA,TPA,T-PA
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MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T45299-Ab-1/ GM-Tg-hg-T45299-Ab-2 | Human t-Plasminogen activator/tPA/PLAT protein | Human |
| GM-Tg-rg-T45299-Ab-1/ GM-Tg-rg-T45299-Ab-2 | Rat t-Plasminogen activator/tPA/PLAT protein | Rat |
| GM-Tg-mg-T45299-Ab-1/ GM-Tg-mg-T45299-Ab-2 | Mouse t-Plasminogen activator/tPA/PLAT protein | Mouse |
| GM-Tg-cynog-T45299-Ab-1/ GM-Tg-cynog-T45299-Ab-2 | Cynomolgus/Rhesus macaque t-Plasminogen activator/tPA/PLAT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T45299-Ab-1/ GM-Tg-felg-T45299-Ab-2 | Feline t-Plasminogen activator/tPA/PLAT protein | Feline |
| GM-Tg-cang-T45299-Ab-1/ GM-Tg-cang-T45299-Ab-2 | Canine t-Plasminogen activator/tPA/PLAT protein | Canine |
| GM-Tg-bovg-T45299-Ab-1/ GM-Tg-bovg-T45299-Ab-2 | Bovine t-Plasminogen activator/tPA/PLAT protein | Bovine |
| GM-Tg-equg-T45299-Ab-1/ GM-Tg-equg-T45299-Ab-2 | Equine t-Plasminogen activator/tPA/PLAT protein | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-T45299-Ab-1/ GM-Tg-hg-T45299-Ab-2;
GM-Tg-rg-T45299-Ab-1/ GM-Tg-rg-T45299-Ab-2;
GM-Tg-mg-T45299-Ab-1/ GM-Tg-mg-T45299-Ab-2; GM-Tg-cynog-T45299-Ab-1/ GM-Tg-cynog-T45299-Ab-2; GM-Tg-felg-T45299-Ab-1/ GM-Tg-felg-T45299-Ab-2; GM-Tg-cang-T45299-Ab-1/ GM-Tg-cang-T45299-Ab-2; GM-Tg-bovg-T45299-Ab-1/ GM-Tg-bovg-T45299-Ab-2; GM-Tg-equg-T45299-Ab-1/ GM-Tg-equg-T45299-Ab-2 |
| Products Name | t-Plasminogen activator/tPA/PLAT protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | t-Plasminogen activator/tPA/PLAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine t-Plasminogen activator/tPA/PLAT protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab
GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.