Recombinant multi-species BCL6/BCL-6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BCL6/BCL-6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
The Alternative Names of target: B-cell lymphoma 5 protein (BCL-5),B-cell lymphoma 6 protein,BCL-6,BCL5,BCL6,BCL6A,Bcl5,Bcl6,LAZ3,Protein LAZ-3,ZBTB27,ZNF51,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51

Target products collectionGo to BCL6/BCL-6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T43548-Ag-1/ GM-Tg-hg-T43548-Ag-2 Human BCL6/BCL-6 protein Human
GM-Tg-rg-T43548-Ag-1/ GM-Tg-rg-T43548-Ag-2 Rat BCL6/BCL-6 protein Rat
GM-Tg-mg-T43548-Ag-1/ GM-Tg-mg-T43548-Ag-2 Mouse BCL6/BCL-6 protein Mouse
GM-Tg-cynog-T43548-Ag-1/ GM-Tg-cynog-T43548-Ag-2 Cynomolgus/Rhesus macaque BCL6/BCL-6 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T43548-Ag-1/ GM-Tg-felg-T43548-Ag-2 Feline BCL6/BCL-6 protein Feline
GM-Tg-cang-T43548-Ag-1/ GM-Tg-cang-T43548-Ag-2 Canine BCL6/BCL-6 protein Canine
GM-Tg-bovg-T43548-Ag-1/ GM-Tg-bovg-T43548-Ag-2 Bovine BCL6/BCL-6 protein Bovine
GM-Tg-equg-T43548-Ag-1/ GM-Tg-equg-T43548-Ag-2 Equine BCL6/BCL-6 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T43548-Ag-1/ GM-Tg-hg-T43548-Ag-2; GM-Tg-rg-T43548-Ag-1/ GM-Tg-rg-T43548-Ag-2;
GM-Tg-mg-T43548-Ag-1/ GM-Tg-mg-T43548-Ag-2; GM-Tg-cynog-T43548-Ag-1/ GM-Tg-cynog-T43548-Ag-2;
GM-Tg-felg-T43548-Ag-1/ GM-Tg-felg-T43548-Ag-2; GM-Tg-cang-T43548-Ag-1/ GM-Tg-cang-T43548-Ag-2;
GM-Tg-bovg-T43548-Ag-1/ GM-Tg-bovg-T43548-Ag-2; GM-Tg-equg-T43548-Ag-1/ GM-Tg-equg-T43548-Ag-2
Products Name BCL6/BCL-6 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name BCL6/BCL-6
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BCL6/BCL-6 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.