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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
| Target ID |
GM-T43548
|
| Target Name |
BCL6/BCL-6
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
604
|
| Gene ID |
100059642 (Equus caballus), 101096665 (Felis catus), 12053 (Mus musculus), 303836 (Rattus norvegicus) 488124 (Canis lupus familiaris), 539020 (Bos taurus), 604 (Homo sapiens), 708736 (Macaca mulatta)
|
| Target Alternative Names |
B-cell lymphoma 5 protein (BCL-5),B-cell lymphoma 6 protein,BCL-6,BCL5,BCL6,BCL6A,Bcl5,Bcl6,LAZ3,Protein LAZ-3,ZBTB27,ZNF51,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51
|
| Uniprot Accession |
P41183,P41182
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
FoxO signaling pathway, Chemical carcinogenesis - receptor activation
|
| Gene Ensembl |
ENSECAG00000004556, ENSMUSG00000022508, ENSCAFG00845022776, ENSBTAG00000001511, ENSG00000113916, ENSMMUG00000009198
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of BCL6/BCL-6 cDNA Clones/ORF Plasmid
BCL6/BCL-6 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo604 | Pre-made Human BCL6/BCL5/LAZ3 siRNA oligo Duplex | 604 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo303836 | Pre-made Rat Bcl6 siRNA oligo Duplex | 303836 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12053 | Pre-made Mouse Bcl6/Bcl5 siRNA oligo Duplex | 12053 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708736 | Pre-made Cynomolgus/Rhesus macaque BCL6 siRNA oligo Duplex | 708736 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096665 | Pre-made Cat/Feline BCL6 siRNA oligo Duplex | 101096665 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488124 | Pre-made Dog/Canine BCL6 siRNA oligo Duplex | 488124 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo539020 | Pre-made Bovines/Cattle BCL6 siRNA oligo Duplex | 539020 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100059642 | Pre-made Equine/Horse BCL6 siRNA oligo Duplex | 100059642 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BCL6/BCL-6 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T43548-Ab | Human | Anti-Human BCL6/BCL-6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T43548-Ab | Rat | Anti-Rat BCL6/BCL-6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T43548-Ab | Mouse | Anti-Mouse BCL6/BCL-6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T43548-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BCL6/BCL-6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T43548-Ab | Cat/Feline | Anti-Cat/Feline BCL6/BCL-6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T43548-Ab | Dog/Canine | Anti-Dog/Canine BCL6/BCL-6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T43548-Ab | Bovines/Cattle | Anti-Bovines/Cattle BCL6/BCL-6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T43548-Ab | Equine/Horse | Anti-Equine/Horse BCL6/BCL-6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
BCL6/BCL-6 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T43548-Ag | Human | Human BCL6/BCL-6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T43548-Ag | Rat | Rat BCL6/BCL-6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T43548-Ag | Mouse | Mouse BCL6/BCL-6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T43548-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BCL6/BCL-6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T43548-Ag | Cat/Feline | Cat/Feline BCL6/BCL-6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T43548-Ag | Dog/Canine | Dog/Canine BCL6/BCL-6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T43548-Ag | Bovines/Cattle | Bovines/Cattle BCL6/BCL-6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T43548-Ag | Equine/Horse | Equine/Horse BCL6/BCL-6 recombinant protein | Mammalian cell | Detail |