Recombinant multi-species GLI1/Gli1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GLI1/Gli1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
The Alternative Names of target: GLI,GLI1,Gli,Gli1,Glioma-associated oncogene,Oncogene GLI,PAPA8,PPD1,Zfp-5,Zfp5,Zinc finger protein GLI1

Target products collectionGo to GLI1/Gli1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T40890-Ag-1/ GM-Tg-hg-T40890-Ag-2 Human GLI1/Gli1 protein Human
GM-Tg-rg-T40890-Ag-1/ GM-Tg-rg-T40890-Ag-2 Rat GLI1/Gli1 protein Rat
GM-Tg-mg-T40890-Ag-1/ GM-Tg-mg-T40890-Ag-2 Mouse GLI1/Gli1 protein Mouse
GM-Tg-cynog-T40890-Ag-1/ GM-Tg-cynog-T40890-Ag-2 Cynomolgus/Rhesus macaque GLI1/Gli1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T40890-Ag-1/ GM-Tg-felg-T40890-Ag-2 Feline GLI1/Gli1 protein Feline
GM-Tg-cang-T40890-Ag-1/ GM-Tg-cang-T40890-Ag-2 Canine GLI1/Gli1 protein Canine
GM-Tg-bovg-T40890-Ag-1/ GM-Tg-bovg-T40890-Ag-2 Bovine GLI1/Gli1 protein Bovine
GM-Tg-equg-T40890-Ag-1/ GM-Tg-equg-T40890-Ag-2 Equine GLI1/Gli1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T40890-Ag-1/ GM-Tg-hg-T40890-Ag-2; GM-Tg-rg-T40890-Ag-1/ GM-Tg-rg-T40890-Ag-2;
GM-Tg-mg-T40890-Ag-1/ GM-Tg-mg-T40890-Ag-2; GM-Tg-cynog-T40890-Ag-1/ GM-Tg-cynog-T40890-Ag-2;
GM-Tg-felg-T40890-Ag-1/ GM-Tg-felg-T40890-Ag-2; GM-Tg-cang-T40890-Ag-1/ GM-Tg-cang-T40890-Ag-2;
GM-Tg-bovg-T40890-Ag-1/ GM-Tg-bovg-T40890-Ag-2; GM-Tg-equg-T40890-Ag-1/ GM-Tg-equg-T40890-Ag-2
Products Name GLI1/Gli1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name GLI1/Gli1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GLI1/Gli1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.