Recombinant multi-species NFKB1/p105 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NFKB1/p105 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020]
The Alternative Names of target: CVID12,DNA-binding factor KBF1,EBP-1,KBF1,NF-KB1,NF-kB,NF-kB1,NF-kappa-B1,NF-kappaB,NF-kappaB1,NF-kappabeta,NFKB-p105,NFKB-p50,NFKB1,NFkappaB,Nfkb1,Nuclear factor NF-kappa-B p105 subunit,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1,p105,p50,p50/p105

Target products collectionGo to NFKB1/p105 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T40192-Ag-1/ GM-Tg-hg-T40192-Ag-2 Human NFKB1/p105 protein Human
GM-Tg-rg-T40192-Ag-1/ GM-Tg-rg-T40192-Ag-2 Rat NFKB1/p105 protein Rat
GM-Tg-mg-T40192-Ag-1/ GM-Tg-mg-T40192-Ag-2 Mouse NFKB1/p105 protein Mouse
GM-Tg-cynog-T40192-Ag-1/ GM-Tg-cynog-T40192-Ag-2 Cynomolgus/Rhesus macaque NFKB1/p105 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T40192-Ag-1/ GM-Tg-felg-T40192-Ag-2 Feline NFKB1/p105 protein Feline
GM-Tg-cang-T40192-Ag-1/ GM-Tg-cang-T40192-Ag-2 Canine NFKB1/p105 protein Canine
GM-Tg-bovg-T40192-Ag-1/ GM-Tg-bovg-T40192-Ag-2 Bovine NFKB1/p105 protein Bovine
GM-Tg-equg-T40192-Ag-1/ GM-Tg-equg-T40192-Ag-2 Equine NFKB1/p105 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T40192-Ag-1/ GM-Tg-hg-T40192-Ag-2; GM-Tg-rg-T40192-Ag-1/ GM-Tg-rg-T40192-Ag-2;
GM-Tg-mg-T40192-Ag-1/ GM-Tg-mg-T40192-Ag-2; GM-Tg-cynog-T40192-Ag-1/ GM-Tg-cynog-T40192-Ag-2;
GM-Tg-felg-T40192-Ag-1/ GM-Tg-felg-T40192-Ag-2; GM-Tg-cang-T40192-Ag-1/ GM-Tg-cang-T40192-Ag-2;
GM-Tg-bovg-T40192-Ag-1/ GM-Tg-bovg-T40192-Ag-2; GM-Tg-equg-T40192-Ag-1/ GM-Tg-equg-T40192-Ag-2
Products Name NFKB1/p105 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name NFKB1/p105
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NFKB1/p105 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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