Recombinant multi-species JNK/MAPK8/JNK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JNK/MAPK8/JNK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
The Alternative Names of target: JNK,JNK-46,JNK1,JNK1A2,JNK21B1/2,MAP kinase 8,MAPK 8,MAPK8,Mapk8,Mitogen-activated protein kinase 8,PRKM8,Prkm8,SAPK1,SAPK1c,Stress-activated protein kinase 1c (SAPK1c),Stress-activated protein kinase JNK1,c-Jun N-terminal kinase 1

Target products collectionGo to JNK/MAPK8/JNK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T40097-Ag-1/ GM-Tg-hg-T40097-Ag-2 Human JNK/MAPK8/JNK1 protein Human
GM-Tg-rg-T40097-Ag-1/ GM-Tg-rg-T40097-Ag-2 Rat JNK/MAPK8/JNK1 protein Rat
GM-Tg-mg-T40097-Ag-1/ GM-Tg-mg-T40097-Ag-2 Mouse JNK/MAPK8/JNK1 protein Mouse
GM-Tg-cynog-T40097-Ag-1/ GM-Tg-cynog-T40097-Ag-2 Cynomolgus/Rhesus macaque JNK/MAPK8/JNK1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T40097-Ag-1/ GM-Tg-felg-T40097-Ag-2 Feline JNK/MAPK8/JNK1 protein Feline
GM-Tg-cang-T40097-Ag-1/ GM-Tg-cang-T40097-Ag-2 Canine JNK/MAPK8/JNK1 protein Canine
GM-Tg-bovg-T40097-Ag-1/ GM-Tg-bovg-T40097-Ag-2 Bovine JNK/MAPK8/JNK1 protein Bovine
GM-Tg-equg-T40097-Ag-1/ GM-Tg-equg-T40097-Ag-2 Equine JNK/MAPK8/JNK1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T40097-Ag-1/ GM-Tg-hg-T40097-Ag-2; GM-Tg-rg-T40097-Ag-1/ GM-Tg-rg-T40097-Ag-2;
GM-Tg-mg-T40097-Ag-1/ GM-Tg-mg-T40097-Ag-2; GM-Tg-cynog-T40097-Ag-1/ GM-Tg-cynog-T40097-Ag-2;
GM-Tg-felg-T40097-Ag-1/ GM-Tg-felg-T40097-Ag-2; GM-Tg-cang-T40097-Ag-1/ GM-Tg-cang-T40097-Ag-2;
GM-Tg-bovg-T40097-Ag-1/ GM-Tg-bovg-T40097-Ag-2; GM-Tg-equg-T40097-Ag-1/ GM-Tg-equg-T40097-Ag-2
Products Name JNK/MAPK8/JNK1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name JNK/MAPK8/JNK1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JNK/MAPK8/JNK1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.