Recombinant multi-species Glucocorticoid receptor/NR3C1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Glucocorticoid receptor/NR3C1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
The Alternative Names of target: GCCR,GCL,GCR,GCRST,GR,GR-A,GRL,Gcr,Glucocorticoid receptor,Grl,Grl-1,Grl1,NR3C1,Nr3c1,Nuclear receptor subfamily 3 group C member 1

Target products collectionGo to Glucocorticoid receptor/NR3C1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T40016-Ag-1/ GM-Tg-hg-T40016-Ag-2 Human Glucocorticoid receptor/NR3C1 protein Human
GM-Tg-rg-T40016-Ag-1/ GM-Tg-rg-T40016-Ag-2 Rat Glucocorticoid receptor/NR3C1 protein Rat
GM-Tg-mg-T40016-Ag-1/ GM-Tg-mg-T40016-Ag-2 Mouse Glucocorticoid receptor/NR3C1 protein Mouse
GM-Tg-cynog-T40016-Ag-1/ GM-Tg-cynog-T40016-Ag-2 Cynomolgus/Rhesus macaque Glucocorticoid receptor/NR3C1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T40016-Ag-1/ GM-Tg-felg-T40016-Ag-2 Feline Glucocorticoid receptor/NR3C1 protein Feline
GM-Tg-cang-T40016-Ag-1/ GM-Tg-cang-T40016-Ag-2 Canine Glucocorticoid receptor/NR3C1 protein Canine
GM-Tg-bovg-T40016-Ag-1/ GM-Tg-bovg-T40016-Ag-2 Bovine Glucocorticoid receptor/NR3C1 protein Bovine
GM-Tg-equg-T40016-Ag-1/ GM-Tg-equg-T40016-Ag-2 Equine Glucocorticoid receptor/NR3C1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T40016-Ag-1/ GM-Tg-hg-T40016-Ag-2; GM-Tg-rg-T40016-Ag-1/ GM-Tg-rg-T40016-Ag-2;
GM-Tg-mg-T40016-Ag-1/ GM-Tg-mg-T40016-Ag-2; GM-Tg-cynog-T40016-Ag-1/ GM-Tg-cynog-T40016-Ag-2;
GM-Tg-felg-T40016-Ag-1/ GM-Tg-felg-T40016-Ag-2; GM-Tg-cang-T40016-Ag-1/ GM-Tg-cang-T40016-Ag-2;
GM-Tg-bovg-T40016-Ag-1/ GM-Tg-bovg-T40016-Ag-2; GM-Tg-equg-T40016-Ag-1/ GM-Tg-equg-T40016-Ag-2
Products Name Glucocorticoid receptor/NR3C1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Glucocorticoid receptor/NR3C1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Glucocorticoid receptor/NR3C1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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