Recombinant multi-species AICDA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AICDA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. AICDA is specifically expressed and active in germinal center-like B cells. In the germinal center, AICDA is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. An epigenetic role in neoplastic transformation and lymphoma progression has been experimentally ascribed to AICDA using mouse models. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Jul 2020]
The Alternative Names of target: AICDA,AID,ARP2,Activation-induced cytidine deaminase (AID),Aicda,Aid,Arp2,CDA2,Cytidine aminohydrolase,HEL-S-284,HIGM2,Single-stranded DNA cytosine deaminase,aid

Target products collectionGo to AICDA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T36467-Ag-1/ GM-Tg-hg-T36467-Ag-2 Human AICDA protein Human
GM-Tg-rg-T36467-Ag-1/ GM-Tg-rg-T36467-Ag-2 Rat AICDA protein Rat
GM-Tg-mg-T36467-Ag-1/ GM-Tg-mg-T36467-Ag-2 Mouse AICDA protein Mouse
GM-Tg-cynog-T36467-Ag-1/ GM-Tg-cynog-T36467-Ag-2 Cynomolgus/Rhesus macaque AICDA protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T36467-Ag-1/ GM-Tg-felg-T36467-Ag-2 Feline AICDA protein Feline
GM-Tg-cang-T36467-Ag-1/ GM-Tg-cang-T36467-Ag-2 Canine AICDA protein Canine
GM-Tg-bovg-T36467-Ag-1/ GM-Tg-bovg-T36467-Ag-2 Bovine AICDA protein Bovine
GM-Tg-equg-T36467-Ag-1/ GM-Tg-equg-T36467-Ag-2 Equine AICDA protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T36467-Ag-1/ GM-Tg-hg-T36467-Ag-2; GM-Tg-rg-T36467-Ag-1/ GM-Tg-rg-T36467-Ag-2;
GM-Tg-mg-T36467-Ag-1/ GM-Tg-mg-T36467-Ag-2; GM-Tg-cynog-T36467-Ag-1/ GM-Tg-cynog-T36467-Ag-2;
GM-Tg-felg-T36467-Ag-1/ GM-Tg-felg-T36467-Ag-2; GM-Tg-cang-T36467-Ag-1/ GM-Tg-cang-T36467-Ag-2;
GM-Tg-bovg-T36467-Ag-1/ GM-Tg-bovg-T36467-Ag-2; GM-Tg-equg-T36467-Ag-1/ GM-Tg-equg-T36467-Ag-2
Products Name AICDA protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name AICDA
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AICDA protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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