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Target
sublocation: Introcelluar Protein.
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. AICDA is specifically expressed and active in germinal center-like B cells. In the germinal center, AICDA is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. An epigenetic role in neoplastic transformation and lymphoma progression has been experimentally ascribed to AICDA using mouse models. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Jul 2020]
| Target ID |
GM-T36467
|
| Target Name |
AICDA
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
57379
|
| Gene ID |
100061137 (Equus caballus), 101101143 (Felis catus), 11628 (Mus musculus), 399679 (Rattus norvegicus)
442983 (Canis lupus familiaris), 539888 (Bos taurus), 57379 (Homo sapiens), 716378 (Macaca mulatta)
|
| Target Alternative Names |
AICDA,AID,ARP2,Activation-induced cytidine deaminase (AID),Aicda,Aid,Arp2,CDA2,Cytidine aminohydrolase,HEL-S-284,HIGM2,Single-stranded DNA cytosine deaminase,aid
|
| Uniprot Accession |
Q9WVE0,Q75W64,Q2PT36,Q9GZX7
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Intestinal immune network for IgA production
|
| Gene Ensembl |
ENSECAG00000018578, ENSMUSG00000040627, ENSCAFG00845029609, ENSBTAG00000018849, ENSG00000111732, ENSMMUG00000019134
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of AICDA cDNA Clones/ORF Plasmid
AICDA siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo57379 | Pre-made Human AICDA/AID/ARP2 siRNA oligo Duplex | 57379 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo399679 | Pre-made Rat Aicda/aid siRNA oligo Duplex | 399679 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11628 | Pre-made Mouse Aicda/Aid/Arp2 siRNA oligo Duplex | 11628 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716378 | Pre-made Cynomolgus/Rhesus macaque AICDA siRNA oligo Duplex | 716378 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101143 | Pre-made Cat/Feline AICDA siRNA oligo Duplex | 101101143 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo442983 | Pre-made Dog/Canine AICDA/AID siRNA oligo Duplex | 442983 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo539888 | Pre-made Bovines/Cattle AICDA/AID siRNA oligo Duplex | 539888 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061137 | Pre-made Equine/Horse AICDA siRNA oligo Duplex | 100061137 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
AICDA antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T36467-Ab | Human | Anti-Human AICDA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T36467-Ab | Rat | Anti-Rat AICDA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T36467-Ab | Mouse | Anti-Mouse AICDA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T36467-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque AICDA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T36467-Ab | Cat/Feline | Anti-Cat/Feline AICDA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T36467-Ab | Dog/Canine | Anti-Dog/Canine AICDA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T36467-Ab | Bovines/Cattle | Anti-Bovines/Cattle AICDA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T36467-Ab | Equine/Horse | Anti-Equine/Horse AICDA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
AICDA recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T36467-Ag | Human | Human AICDA recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T36467-Ag | Rat | Rat AICDA recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T36467-Ag | Mouse | Mouse AICDA recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T36467-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque AICDA recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T36467-Ag | Cat/Feline | Cat/Feline AICDA recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T36467-Ag | Dog/Canine | Dog/Canine AICDA recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T36467-Ag | Bovines/Cattle | Bovines/Cattle AICDA recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T36467-Ag | Equine/Horse | Equine/Horse AICDA recombinant protein | Mammalian cell | Detail |
