Recombinant multi-species MLH1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MLH1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
The Alternative Names of target: 1110035C23Rik,COCA2,DNA mismatch repair protein Mlh1,FCC2,HNPCC,HNPCC2,LYNCH2,MLH-1,MLH1,MMRCS1,Mlh1,MutL protein homolog 1,hMLH1

Target products collectionGo to MLH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T35799-Ag-1/ GM-Tg-hg-T35799-Ag-2 Human MLH1 protein Human
GM-Tg-rg-T35799-Ag-1/ GM-Tg-rg-T35799-Ag-2 Rat MLH1 protein Rat
GM-Tg-mg-T35799-Ag-1/ GM-Tg-mg-T35799-Ag-2 Mouse MLH1 protein Mouse
GM-Tg-cynog-T35799-Ag-1/ GM-Tg-cynog-T35799-Ag-2 Cynomolgus/Rhesus macaque MLH1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T35799-Ag-1/ GM-Tg-felg-T35799-Ag-2 Feline MLH1 protein Feline
GM-Tg-cang-T35799-Ag-1/ GM-Tg-cang-T35799-Ag-2 Canine MLH1 protein Canine
GM-Tg-bovg-T35799-Ag-1/ GM-Tg-bovg-T35799-Ag-2 Bovine MLH1 protein Bovine
GM-Tg-equg-T35799-Ag-1/ GM-Tg-equg-T35799-Ag-2 Equine MLH1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T35799-Ag-1/ GM-Tg-hg-T35799-Ag-2; GM-Tg-rg-T35799-Ag-1/ GM-Tg-rg-T35799-Ag-2;
GM-Tg-mg-T35799-Ag-1/ GM-Tg-mg-T35799-Ag-2; GM-Tg-cynog-T35799-Ag-1/ GM-Tg-cynog-T35799-Ag-2;
GM-Tg-felg-T35799-Ag-1/ GM-Tg-felg-T35799-Ag-2; GM-Tg-cang-T35799-Ag-1/ GM-Tg-cang-T35799-Ag-2;
GM-Tg-bovg-T35799-Ag-1/ GM-Tg-bovg-T35799-Ag-2; GM-Tg-equg-T35799-Ag-1/ GM-Tg-equg-T35799-Ag-2
Products Name MLH1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MLH1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MLH1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.