Explore MLH1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
| Target ID |
GM-T35799
|
| Target Name |
MLH1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4292
|
| Gene ID |
100050351 (Equus caballus), 101089037 (Felis catus), 17350 (Mus musculus), 4292 (Homo sapiens)
477019 (Canis lupus familiaris), 533652 (Bos taurus), 698782 (Macaca mulatta), 81685 (Rattus norvegicus)
|
| Target Alternative Names |
1110035C23Rik,COCA2,DNA mismatch repair protein Mlh1,FCC2,HNPCC,HNPCC2,LYNCH2,MLH-1,MLH1,MMRCS1,Mlh1,MutL protein homolog 1,hMLH1
|
| Uniprot Accession |
Q9JK91,P40692,P97679
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Colorectal Cancer
|
| Disease from KEGG |
Pathways in cancer, Colorectal cancer, Endometrial cancer, Gastric cancer
|
| Gene Ensembl |
ENSECAG00000000690, ENSMUSG00000032498, ENSG00000076242, ENSCAFG00845027002, ENSBTAG00000016758, ENSMMUG00000022533
|
Pre-made viral vector of MLH1 cDNA Clones/ORF Plasmid
MLH1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4292 | Pre-made Human MLH1/FCC2/COCA2 siRNA oligo Duplex | 4292 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81685 | Pre-made Rat Mlh1 siRNA oligo Duplex | 81685 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17350 | Pre-made Mouse Mlh1/1110035C23Rik siRNA oligo Duplex | 17350 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698782 | Pre-made Cynomolgus/Rhesus macaque MLH1 siRNA oligo Duplex | 698782 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089037 | Pre-made Cat/Feline MLH1 siRNA oligo Duplex | 101089037 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477019 | Pre-made Dog/Canine MLH1 siRNA oligo Duplex | 477019 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo533652 | Pre-made Bovines/Cattle MLH1 siRNA oligo Duplex | 533652 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100050351 | Pre-made Equine/Horse MLH1 siRNA oligo Duplex | 100050351 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MLH1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T35799-Ab | Human | Anti-Human MLH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T35799-Ab | Rat | Anti-Rat MLH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T35799-Ab | Mouse | Anti-Mouse MLH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T35799-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MLH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T35799-Ab | Cat/Feline | Anti-Cat/Feline MLH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T35799-Ab | Dog/Canine | Anti-Dog/Canine MLH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T35799-Ab | Bovines/Cattle | Anti-Bovines/Cattle MLH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T35799-Ab | Equine/Horse | Anti-Equine/Horse MLH1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
MLH1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T35799-Ag | Human | Human MLH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T35799-Ag | Rat | Rat MLH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T35799-Ag | Mouse | Mouse MLH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T35799-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MLH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T35799-Ag | Cat/Feline | Cat/Feline MLH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T35799-Ag | Dog/Canine | Dog/Canine MLH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T35799-Ag | Bovines/Cattle | Bovines/Cattle MLH1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T35799-Ag | Equine/Horse | Equine/Horse MLH1 recombinant protein | Mammalian cell | Detail |
