Recombinant multi-species VDR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine VDR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]
The Alternative Names of target: 1,25-dihydroxyvitamin D3 receptor,NR1I1,Nr1i1,Nuclear receptor subfamily 1 group I member 1,PPP1R163,VDR,Vdr,Vitamin D3 receptor

Target products collectionGo to VDR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T34234-Ag-1/ GM-Tg-hg-T34234-Ag-2 Human VDR protein Human
GM-Tg-rg-T34234-Ag-1/ GM-Tg-rg-T34234-Ag-2 Rat VDR protein Rat
GM-Tg-mg-T34234-Ag-1/ GM-Tg-mg-T34234-Ag-2 Mouse VDR protein Mouse
GM-Tg-cynog-T34234-Ag-1/ GM-Tg-cynog-T34234-Ag-2 Cynomolgus/Rhesus macaque VDR protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T34234-Ag-1/ GM-Tg-felg-T34234-Ag-2 Feline VDR protein Feline
GM-Tg-cang-T34234-Ag-1/ GM-Tg-cang-T34234-Ag-2 Canine VDR protein Canine
GM-Tg-bovg-T34234-Ag-1/ GM-Tg-bovg-T34234-Ag-2 Bovine VDR protein Bovine
GM-Tg-equg-T34234-Ag-1/ GM-Tg-equg-T34234-Ag-2 Equine VDR protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T34234-Ag-1/ GM-Tg-hg-T34234-Ag-2; GM-Tg-rg-T34234-Ag-1/ GM-Tg-rg-T34234-Ag-2;
GM-Tg-mg-T34234-Ag-1/ GM-Tg-mg-T34234-Ag-2; GM-Tg-cynog-T34234-Ag-1/ GM-Tg-cynog-T34234-Ag-2;
GM-Tg-felg-T34234-Ag-1/ GM-Tg-felg-T34234-Ag-2; GM-Tg-cang-T34234-Ag-1/ GM-Tg-cang-T34234-Ag-2;
GM-Tg-bovg-T34234-Ag-1/ GM-Tg-bovg-T34234-Ag-2; GM-Tg-equg-T34234-Ag-1/ GM-Tg-equg-T34234-Ag-2
Products Name VDR protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name VDR
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine VDR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.