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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]
| Target ID |
GM-T34234
|
| Target Name |
VDR
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7421
|
| Gene ID |
100034072 (Equus caballus), 100316614 (Felis catus), 22337 (Mus musculus), 24873 (Rattus norvegicus) 486588 (Canis lupus familiaris), 533656 (Bos taurus), 706964 (Macaca mulatta), 7421 (Homo sapiens)
|
| Target Alternative Names |
1,25-dihydroxyvitamin D3 receptor,NR1I1,Nr1i1,Nuclear receptor subfamily 1 group I member 1,PPP1R163,VDR,Vdr,Vitamin D3 receptor
|
| Uniprot Accession |
P48281,P13053,Q28037,P11473
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Parathyroid hormone synthesis, secretion and action, Mineral absorption, Tuberculosis, Chemical carcinogenesis - receptor activation
|
| Gene Ensembl |
ENSECAG00000015822, ENSMUSG00000022479, ENSCAFG00845024745, ENSBTAG00000016414, ENSMMUG00000006727, ENSG00000111424
|
Pre-made viral vector of VDR cDNA Clones/ORF Plasmid
VDR siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7421 | Pre-made Human VDR/NR1I1/PPP1R163 siRNA oligo Duplex | 7421 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24873 | Pre-made Rat Vdr/Nr1i1 siRNA oligo Duplex | 24873 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22337 | Pre-made Mouse Vdr/Nr1i1 siRNA oligo Duplex | 22337 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo706964 | Pre-made Cynomolgus/Rhesus macaque VDR siRNA oligo Duplex | 706964 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100316614 | Pre-made Cat/Feline VDR siRNA oligo Duplex | 100316614 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486588 | Pre-made Dog/Canine VDR siRNA oligo Duplex | 486588 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo533656 | Pre-made Bovines/Cattle VDR siRNA oligo Duplex | 533656 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034072 | Pre-made Equine/Horse VDR siRNA oligo Duplex | 100034072 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
VDR antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T34234-Ab | Human | Anti-Human VDR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T34234-Ab | Rat | Anti-Rat VDR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T34234-Ab | Mouse | Anti-Mouse VDR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T34234-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque VDR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T34234-Ab | Cat/Feline | Anti-Cat/Feline VDR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T34234-Ab | Dog/Canine | Anti-Dog/Canine VDR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T34234-Ab | Bovines/Cattle | Anti-Bovines/Cattle VDR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T34234-Ab | Equine/Horse | Anti-Equine/Horse VDR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
VDR recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T34234-Ag | Human | Human VDR recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T34234-Ag | Rat | Rat VDR recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T34234-Ag | Mouse | Mouse VDR recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T34234-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque VDR recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T34234-Ag | Cat/Feline | Cat/Feline VDR recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T34234-Ag | Dog/Canine | Dog/Canine VDR recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T34234-Ag | Bovines/Cattle | Bovines/Cattle VDR recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T34234-Ag | Equine/Horse | Equine/Horse VDR recombinant protein | Mammalian cell | Detail |