Recombinant multi-species PHD2/EGLN1/HPH-2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PHD2/EGLN1/HPH-2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]
The Alternative Names of target: C1orf12,ECYT3,EGLN1,Egl nine homolog 1,Egln1,HALAH,HIF-PH2,HIF-prolyl hydroxylase 2,HIFPH2,HPH-2,HPH-2),HPH2,Hif-p4h-2,Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2,ORF13,PHD-2,PHD2,Phd2,Prolyl hydroxylase domain-containing protein 2 (PHD2),SM-20,SM20,ZMYND6

Target products collectionGo to PHD2/EGLN1/HPH-2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T32880-Ag-1/ GM-Tg-hg-T32880-Ag-2 Human PHD2/EGLN1/HPH-2 protein Human
GM-Tg-rg-T32880-Ag-1/ GM-Tg-rg-T32880-Ag-2 Rat PHD2/EGLN1/HPH-2 protein Rat
GM-Tg-mg-T32880-Ag-1/ GM-Tg-mg-T32880-Ag-2 Mouse PHD2/EGLN1/HPH-2 protein Mouse
GM-Tg-cynog-T32880-Ag-1/ GM-Tg-cynog-T32880-Ag-2 Cynomolgus/Rhesus macaque PHD2/EGLN1/HPH-2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T32880-Ag-1/ GM-Tg-felg-T32880-Ag-2 Feline PHD2/EGLN1/HPH-2 protein Feline
GM-Tg-cang-T32880-Ag-1/ GM-Tg-cang-T32880-Ag-2 Canine PHD2/EGLN1/HPH-2 protein Canine
GM-Tg-bovg-T32880-Ag-1/ GM-Tg-bovg-T32880-Ag-2 Bovine PHD2/EGLN1/HPH-2 protein Bovine
GM-Tg-equg-T32880-Ag-1/ GM-Tg-equg-T32880-Ag-2 Equine PHD2/EGLN1/HPH-2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T32880-Ag-1/ GM-Tg-hg-T32880-Ag-2; GM-Tg-rg-T32880-Ag-1/ GM-Tg-rg-T32880-Ag-2;
GM-Tg-mg-T32880-Ag-1/ GM-Tg-mg-T32880-Ag-2; GM-Tg-cynog-T32880-Ag-1/ GM-Tg-cynog-T32880-Ag-2;
GM-Tg-felg-T32880-Ag-1/ GM-Tg-felg-T32880-Ag-2; GM-Tg-cang-T32880-Ag-1/ GM-Tg-cang-T32880-Ag-2;
GM-Tg-bovg-T32880-Ag-1/ GM-Tg-bovg-T32880-Ag-2; GM-Tg-equg-T32880-Ag-1/ GM-Tg-equg-T32880-Ag-2
Products Name PHD2/EGLN1/HPH-2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PHD2/EGLN1/HPH-2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PHD2/EGLN1/HPH-2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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