Explore PHD2/EGLN1/HPH-2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]
| Target ID |
GM-T32880
|
| Target Name |
PHD2/EGLN1/HPH-2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
54583
|
| Gene ID |
100060551 (Equus caballus), 101089964 (Felis catus), 112405 (Mus musculus), 308913 (Rattus norvegicus)
488971 (Canis lupus familiaris), 534075 (Bos taurus), 54583 (Homo sapiens), 713410 (Macaca mulatta)
|
| Target Alternative Names |
C1orf12,ECYT3,EGLN1,Egl nine homolog 1,Egln1,HALAH,HIF-PH2,HIF-prolyl hydroxylase 2,HIFPH2,HPH-2,HPH-2),HPH2,Hif-p4h-2,Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2,ORF13,PHD-2,PHD2,Phd2,Prolyl hydroxylase domain-containing protein 2 (PHD2),SM-20,SM20,ZMYND6
|
| Uniprot Accession |
Q91YE3,P59722,Q9GZT9
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Breast Cancer
|
| Disease from KEGG |
HIF-1 signaling pathway, Pathways in cancer, Renal cell carcinoma
|
| Gene Ensembl |
ENSECAG00000021704, ENSMUSG00000031987, ENSCAFG00845000514, ENSBTAG00000053296, ENSG00000135766, ENSMMUG00000053396
|
PHD2/EGLN1/HPH-2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo54583 | Pre-made Human EGLN1/HPH2/PHD2 siRNA oligo Duplex | 54583 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo308913 | Pre-made Rat Egln1/PHD2/HPH-2 siRNA oligo Duplex | 308913 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo112405 | Pre-made Mouse Egln1/Phd2/HPH-2 siRNA oligo Duplex | 112405 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo713410 | Pre-made Cynomolgus/Rhesus macaque EGLN1 siRNA oligo Duplex | 713410 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089964 | Pre-made Cat/Feline EGLN1 siRNA oligo Duplex | 101089964 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488971 | Pre-made Dog/Canine EGLN1 siRNA oligo Duplex | 488971 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534075 | Pre-made Bovines/Cattle EGLN1 siRNA oligo Duplex | 534075 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060551 | Pre-made Equine/Horse EGLN1 siRNA oligo Duplex | 100060551 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PHD2/EGLN1/HPH-2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T32880-Ab | Human | Anti-Human PHD2/EGLN1/HPH-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T32880-Ab | Rat | Anti-Rat PHD2/EGLN1/HPH-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T32880-Ab | Mouse | Anti-Mouse PHD2/EGLN1/HPH-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T32880-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PHD2/EGLN1/HPH-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T32880-Ab | Cat/Feline | Anti-Cat/Feline PHD2/EGLN1/HPH-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T32880-Ab | Dog/Canine | Anti-Dog/Canine PHD2/EGLN1/HPH-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T32880-Ab | Bovines/Cattle | Anti-Bovines/Cattle PHD2/EGLN1/HPH-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T32880-Ab | Equine/Horse | Anti-Equine/Horse PHD2/EGLN1/HPH-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PHD2/EGLN1/HPH-2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T32880-Ag | Human | Human PHD2/EGLN1/HPH-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T32880-Ag | Rat | Rat PHD2/EGLN1/HPH-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T32880-Ag | Mouse | Mouse PHD2/EGLN1/HPH-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T32880-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PHD2/EGLN1/HPH-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T32880-Ag | Cat/Feline | Cat/Feline PHD2/EGLN1/HPH-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T32880-Ag | Dog/Canine | Dog/Canine PHD2/EGLN1/HPH-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T32880-Ag | Bovines/Cattle | Bovines/Cattle PHD2/EGLN1/HPH-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T32880-Ag | Equine/Horse | Equine/Horse PHD2/EGLN1/HPH-2 recombinant protein | Mammalian cell | Detail |
