Recombinant multi-species IL-6/IL6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-6/IL6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]
The Alternative Names of target: B-cell stimulatory factor 2 (BSF-2),BSF-2,BSF2,CDF,CTL differentiation factor (CDF),HGF,HSF,Hybridoma growth factor,IFN-beta-2,IFNB2,IL-6,IL6,ILg6,Ifnb2,Il-6,Il6,Interferon beta-2 (IFN-beta-2),Interleukin-6

Target products collectionGo to IL-6/IL6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T32578-Ag-1/ GM-Tg-hg-T32578-Ag-2 Human IL-6/IL6 protein Human
GM-Tg-rg-T32578-Ag-1/ GM-Tg-rg-T32578-Ag-2 Rat IL-6/IL6 protein Rat
GM-Tg-mg-T32578-Ag-1/ GM-Tg-mg-T32578-Ag-2 Mouse IL-6/IL6 protein Mouse
GM-Tg-cynog-T32578-Ag-1/ GM-Tg-cynog-T32578-Ag-2 Cynomolgus/Rhesus macaque IL-6/IL6 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T32578-Ag-1/ GM-Tg-felg-T32578-Ag-2 Feline IL-6/IL6 protein Feline
GM-Tg-cang-T32578-Ag-1/ GM-Tg-cang-T32578-Ag-2 Canine IL-6/IL6 protein Canine
GM-Tg-bovg-T32578-Ag-1/ GM-Tg-bovg-T32578-Ag-2 Bovine IL-6/IL6 protein Bovine
GM-Tg-equg-T32578-Ag-1/ GM-Tg-equg-T32578-Ag-2 Equine IL-6/IL6 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T32578-Ag-1/ GM-Tg-hg-T32578-Ag-2; GM-Tg-rg-T32578-Ag-1/ GM-Tg-rg-T32578-Ag-2;
GM-Tg-mg-T32578-Ag-1/ GM-Tg-mg-T32578-Ag-2; GM-Tg-cynog-T32578-Ag-1/ GM-Tg-cynog-T32578-Ag-2;
GM-Tg-felg-T32578-Ag-1/ GM-Tg-felg-T32578-Ag-2; GM-Tg-cang-T32578-Ag-1/ GM-Tg-cang-T32578-Ag-2;
GM-Tg-bovg-T32578-Ag-1/ GM-Tg-bovg-T32578-Ag-2; GM-Tg-equg-T32578-Ag-1/ GM-Tg-equg-T32578-Ag-2
Products Name IL-6/IL6 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IL-6/IL6
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-6/IL6 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.