Recombinant multi-species IL-15/IL15 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-15/IL15 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
The Alternative Names of target: IL-15,IL15,Il15,Interleukin-15

Target products collectionGo to IL-15/IL15 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T32240-Ag-1/ GM-Tg-hg-T32240-Ag-2 Human IL-15/IL15 protein Human
GM-Tg-rg-T32240-Ag-1/ GM-Tg-rg-T32240-Ag-2 Rat IL-15/IL15 protein Rat
GM-Tg-mg-T32240-Ag-1/ GM-Tg-mg-T32240-Ag-2 Mouse IL-15/IL15 protein Mouse
GM-Tg-cynog-T32240-Ag-1/ GM-Tg-cynog-T32240-Ag-2 Cynomolgus/Rhesus macaque IL-15/IL15 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T32240-Ag-1/ GM-Tg-felg-T32240-Ag-2 Feline IL-15/IL15 protein Feline
GM-Tg-cang-T32240-Ag-1/ GM-Tg-cang-T32240-Ag-2 Canine IL-15/IL15 protein Canine
GM-Tg-bovg-T32240-Ag-1/ GM-Tg-bovg-T32240-Ag-2 Bovine IL-15/IL15 protein Bovine
GM-Tg-equg-T32240-Ag-1/ GM-Tg-equg-T32240-Ag-2 Equine IL-15/IL15 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T32240-Ag-1/ GM-Tg-hg-T32240-Ag-2; GM-Tg-rg-T32240-Ag-1/ GM-Tg-rg-T32240-Ag-2;
GM-Tg-mg-T32240-Ag-1/ GM-Tg-mg-T32240-Ag-2; GM-Tg-cynog-T32240-Ag-1/ GM-Tg-cynog-T32240-Ag-2;
GM-Tg-felg-T32240-Ag-1/ GM-Tg-felg-T32240-Ag-2; GM-Tg-cang-T32240-Ag-1/ GM-Tg-cang-T32240-Ag-2;
GM-Tg-bovg-T32240-Ag-1/ GM-Tg-bovg-T32240-Ag-2; GM-Tg-equg-T32240-Ag-1/ GM-Tg-equg-T32240-Ag-2
Products Name IL-15/IL15 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IL-15/IL15
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-15/IL15 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.