Explore IL-15/IL15 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
| Target ID |
GM-T32240
|
| Target Name |
IL-15/IL15
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3600
|
| Gene ID |
100034058 (Equus caballus), 16168 (Mus musculus), 25670 (Rattus norvegicus), 281248 (Bos taurus) 3600 (Homo sapiens), 403584 (Canis lupus familiaris), 493682 (Felis catus), 699616 (Macaca mulatta)
|
| Target Alternative Names |
IL-15,IL15,Il15,Interleukin-15
|
| Uniprot Accession |
P48346,P97604,Q28028,P40933,O97687,P48092
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, TNF signaling pathway, Intestinal immune network for IgA production, Human T-cell leukemia virus 1 infection, Pathways in cancer, Rheumatoid arthritis
|
| Gene Ensembl |
ENSECAG00000014406, ENSMUSG00000031712, ENSBTAG00000018200, ENSG00000164136, ENSCAFG00845019627, ENSMMUG00000019092
|
| Target Classification |
Cytokine Receptor, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of IL-15/IL15 cDNA Clones/ORF Plasmid
IL-15/IL15 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3600 | Pre-made Human IL15/IL-15 siRNA oligo Duplex | 3600 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25670 | Pre-made Rat Il15 siRNA oligo Duplex | 25670 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16168 | Pre-made Mouse Il15/IL-15 siRNA oligo Duplex | 16168 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699616 | Pre-made Cynomolgus/Rhesus macaque IL15/IL-15 siRNA oligo Duplex | 699616 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493682 | Pre-made Cat/Feline IL15 siRNA oligo Duplex | 493682 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403584 | Pre-made Dog/Canine IL15 siRNA oligo Duplex | 403584 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281248 | Pre-made Bovines/Cattle IL15 siRNA oligo Duplex | 281248 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034058 | Pre-made Equine/Horse IL15 siRNA oligo Duplex | 100034058 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IL-15/IL15 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T32240-Ab | Human | Anti-Human IL-15/IL15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T32240-Ab | Rat | Anti-Rat IL-15/IL15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T32240-Ab | Mouse | Anti-Mouse IL-15/IL15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T32240-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IL-15/IL15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T32240-Ab | Cat/Feline | Anti-Cat/Feline IL-15/IL15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T32240-Ab | Dog/Canine | Anti-Dog/Canine IL-15/IL15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T32240-Ab | Bovines/Cattle | Anti-Bovines/Cattle IL-15/IL15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T32240-Ab | Equine/Horse | Anti-Equine/Horse IL-15/IL15 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
IL-15/IL15 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T32240-Ag | Human | Human IL-15/IL15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T32240-Ag | Rat | Rat IL-15/IL15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T32240-Ag | Mouse | Mouse IL-15/IL15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T32240-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IL-15/IL15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T32240-Ag | Cat/Feline | Cat/Feline IL-15/IL15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T32240-Ag | Dog/Canine | Dog/Canine IL-15/IL15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T32240-Ag | Bovines/Cattle | Bovines/Cattle IL-15/IL15 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T32240-Ag | Equine/Horse | Equine/Horse IL-15/IL15 recombinant protein | Mammalian cell | Detail |