Recombinant multi-species Iduronate 2 sulfatase/IDS protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Iduronate 2 sulfatase/IDS protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
The Alternative Names of target: Alpha-L-iduronate sulfate sulfatase (Idursulfase),ID2S,IDS,Ids,Iduronate 2 sulfatase,Iduronate 2-sulfatase,MPS2,SIDS
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Product information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T28993-Ag-1/ GM-Tg-hg-T28993-Ag-2 | Human Iduronate 2 sulfatase/IDS protein | Human |
| GM-Tg-rg-T28993-Ag-1/ GM-Tg-rg-T28993-Ag-2 | Rat Iduronate 2 sulfatase/IDS protein | Rat |
| GM-Tg-mg-T28993-Ag-1/ GM-Tg-mg-T28993-Ag-2 | Mouse Iduronate 2 sulfatase/IDS protein | Mouse |
| GM-Tg-cynog-T28993-Ag-1/ GM-Tg-cynog-T28993-Ag-2 | Cynomolgus/Rhesus macaque Iduronate 2 sulfatase/IDS protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T28993-Ag-1/ GM-Tg-felg-T28993-Ag-2 | Feline Iduronate 2 sulfatase/IDS protein | Feline |
| GM-Tg-cang-T28993-Ag-1/ GM-Tg-cang-T28993-Ag-2 | Canine Iduronate 2 sulfatase/IDS protein | Canine |
| GM-Tg-bovg-T28993-Ag-1/ GM-Tg-bovg-T28993-Ag-2 | Bovine Iduronate 2 sulfatase/IDS protein | Bovine |
| GM-Tg-equg-T28993-Ag-1/ GM-Tg-equg-T28993-Ag-2 | Equine Iduronate 2 sulfatase/IDS protein | Equine |
Size: 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-T28993-Ag-1/ GM-Tg-hg-T28993-Ag-2;
GM-Tg-rg-T28993-Ag-1/ GM-Tg-rg-T28993-Ag-2;
GM-Tg-mg-T28993-Ag-1/ GM-Tg-mg-T28993-Ag-2; GM-Tg-cynog-T28993-Ag-1/ GM-Tg-cynog-T28993-Ag-2; GM-Tg-felg-T28993-Ag-1/ GM-Tg-felg-T28993-Ag-2; GM-Tg-cang-T28993-Ag-1/ GM-Tg-cang-T28993-Ag-2; GM-Tg-bovg-T28993-Ag-1/ GM-Tg-bovg-T28993-Ag-2; GM-Tg-equg-T28993-Ag-1/ GM-Tg-equg-T28993-Ag-2 |
| Products Name | Iduronate 2 sulfatase/IDS protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | Iduronate 2 sulfatase/IDS |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Iduronate 2 sulfatase/IDS protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
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GMab, developed by GeneMedi, constitutes an
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pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
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