Recombinant multi-species GCH1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GCH1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]
The Alternative Names of target: DYT14,DYT5,DYT5a,GCH,GCH1,GTP cyclohydrolase 1,GTP cyclohydrolase I (GTP-CH-I),GTP-CH,GTP-CH-1,GTP-CH-I,GTPCH,GTPCH-1,GTPCH1,Gch,Gch1,HPABH4B

Target products collectionGo to GCH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T28226-Ag-1/ GM-Tg-hg-T28226-Ag-2 Human GCH1 protein Human
GM-Tg-rg-T28226-Ag-1/ GM-Tg-rg-T28226-Ag-2 Rat GCH1 protein Rat
GM-Tg-mg-T28226-Ag-1/ GM-Tg-mg-T28226-Ag-2 Mouse GCH1 protein Mouse
GM-Tg-cynog-T28226-Ag-1/ GM-Tg-cynog-T28226-Ag-2 Cynomolgus/Rhesus macaque GCH1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T28226-Ag-1/ GM-Tg-felg-T28226-Ag-2 Feline GCH1 protein Feline
GM-Tg-cang-T28226-Ag-1/ GM-Tg-cang-T28226-Ag-2 Canine GCH1 protein Canine
GM-Tg-bovg-T28226-Ag-1/ GM-Tg-bovg-T28226-Ag-2 Bovine GCH1 protein Bovine
GM-Tg-equg-T28226-Ag-1/ GM-Tg-equg-T28226-Ag-2 Equine GCH1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T28226-Ag-1/ GM-Tg-hg-T28226-Ag-2; GM-Tg-rg-T28226-Ag-1/ GM-Tg-rg-T28226-Ag-2;
GM-Tg-mg-T28226-Ag-1/ GM-Tg-mg-T28226-Ag-2; GM-Tg-cynog-T28226-Ag-1/ GM-Tg-cynog-T28226-Ag-2;
GM-Tg-felg-T28226-Ag-1/ GM-Tg-felg-T28226-Ag-2; GM-Tg-cang-T28226-Ag-1/ GM-Tg-cang-T28226-Ag-2;
GM-Tg-bovg-T28226-Ag-1/ GM-Tg-bovg-T28226-Ag-2; GM-Tg-equg-T28226-Ag-1/ GM-Tg-equg-T28226-Ag-2
Products Name GCH1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name GCH1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GCH1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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